机构：[1]The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.[2]Yunnan Health Cell Biotechnology LTD, Kunming 650031, China.[3]Yunnan Province Key Laboratory of Children's Major Diseases Research, The Affiliated Children Hospital, Kunming Medical University, Kunming 650030, China.
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has severely affected socio-economic conditions and people's life. The lung is the major target organ infected and (seriously) damaged by SARS-CoV-2, so a comprehensive understanding of the virus and the mechanism of infection are the first choices to overcome COVID-19. Recent studies have demonstrated the enormous value of human organoids as platforms for virological research, making them an ideal tool for researching host-pathogen interactions. In this study, the various existing lung organoids and their identification biomarkers and applications are summarized. At the same time, the seven coronaviruses currently capable of infecting humans are outlined. Finally, a detailed summary of existing studies on SARS-CoV-2 using lung organoids is provided and includes pathogenesis, drug development, and precision treatment. This review highlights the value of lung organoids in studying SARS-CoV-2 infection, bringing hope that research will alleviate COVID-19-associated lung infections.
基金：
This research was funded by the National Natural Science Foundation of China (No.
32060180, 82160304, 81560596, 81860644, and 31560051) and the Natural Foundation of Yunnan
Province (2017FE467-001, 2019FE001-002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区生物学
小类|3 区细胞生物学
最新[2023]版：
大类|2 区生物学
小类|3 区细胞生物学
第一作者：
第一作者机构：[1]The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
通讯作者：
通讯机构：[1]The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.[2]Yunnan Health Cell Biotechnology LTD, Kunming 650031, China.[3]Yunnan Province Key Laboratory of Children's Major Diseases Research, The Affiliated Children Hospital, Kunming Medical University, Kunming 650030, China.
推荐引用方式(GB/T 7714)：
Peng Li,Gao Li,Wu Xinya,et al.Lung Organoids as Model to Study SARS-CoV-2 Infection[J].Cells.2022,11(17):doi:10.3390/cells11172758.
APA：
Peng Li,Gao Li,Wu Xinya,Fan Yuxin,Liu Meixiao...&Bao Fukai.(2022).Lung Organoids as Model to Study SARS-CoV-2 Infection.Cells,11,(17)
MLA：
Peng Li,et al."Lung Organoids as Model to Study SARS-CoV-2 Infection".Cells 11..17(2022)
