机构：[1]Lishui City People’s Hospital, Lishui, Zhejiang 323000, People’s Republic of China[2]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, China[3]National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, China[4]Genetic Testing Center, The First Affiliated Hospital of Dali University, Dali University, Dali, China
This study aimed to investigate the potential effects of wasp venom (WV) from Vespa magnifica on antithrombosis in rats with inferior vena cava (IVC) thrombosis.The thrombosis rat model was established by improving the IVC stenosis, in which rats were subjected to IVC ligation for 75 min. Rats were administered argatroban (IP) or WV (s.c.) for 4 hr after IVC thrombosis. The weight, inhibition rate, and pathological morphology of the thrombosis induced by IVC ligation and the variation in four coagulation parameters, coagulation factors, and CD61+CD62P+ were simultaneously determined in IVC rats.The thrombus formed as a result of IVC ligation was stable. Compared with the control group, the weight of the thrombus was significantly reduced in the argatroban group. Thrombus weight was reduced by treatment with 0.6, 0.2, and 0.05 mg/kg WV, with inhibition rates of 52.19%, 35.32%, and 28.98%, respectively. Inflammatory cells adhered to and infiltrated the vessel wall in the IVC group more than in the sham group. However, the pathological morphology and CD61+CD62P+ of the WV treatment groups tended to be normal.We improved the model of IVC thrombosis to be suitable for evaluation of antithrombotic drugs. Our findings demonstrated that WV could inhibit IVC thrombosis associated with reducing coagulation factors V and CD61+CD62p expression in rats.
基金：
This work was partially supported by the National Natural
Science Foundation of China (grant number: 81703742 and
81360679) and The Natural Science Foundation of Yunnan
Province (grant number: 2017FA050 and 2019FB121).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
第一作者：
第一作者机构：[1]Lishui City People’s Hospital, Lishui, Zhejiang 323000, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[2]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, China[3]National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, China[4]Genetic Testing Center, The First Affiliated Hospital of Dali University, Dali University, Dali, China[*1]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, China[*2]National- Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, China[*3]Genetic Testing Center, The First Affiliated Hospital of Dali University, Dali University, Dali, China
推荐引用方式(GB/T 7714)：
Fan-mao Jin #,Mei Wang #,Xiu-mei Wu,et al.Effects of wasp venom on venous thrombosis in rats[J].Iranian journal of basic medical sciences.2022,25(7):822-826.doi:10.22038/IJBMS.2022.63219.13962.
APA：
Fan-mao Jin #,Mei Wang #,Xiu-mei Wu,Huai Xiao,De-xiao Wang...&Hai-rong Zhao.(2022).Effects of wasp venom on venous thrombosis in rats.Iranian journal of basic medical sciences,25,(7)
MLA：
Fan-mao Jin #,et al."Effects of wasp venom on venous thrombosis in rats".Iranian journal of basic medical sciences 25..7(2022):822-826
