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Activation of lymphangiogenesis by platelet as novel therapeutic approaches for liver cirrhosis and portal hypertension

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机构： [1]Department of General Surgery, The First People's Hospital of Dali City, Dali 671000, Yunnan Province, China. [2]Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China. [3]Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China. [4]Division of Hepatobiliary Surgery, Department of Surgical Education and Research, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China. keyang1218@126.com.

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关键词： Portal hypertension Liver cirrhosis Lymphangiogenesis Platelets Vascular endothelial growth factor C

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This letter comments on the recently published article in the World Journal of Gastroenterology, in which the authors demonstrated a strong link between lymphangiogenesis and the process of platelet adherence, aggregation, and activation by employing a rat model of liver cirrhosis caused by bile duct ligation (BDL). The authors applied both gain and loss of function approach by using platelet-rich plasma and vascular endothelial growth factor 3 receptor inhibitor MAZ-51 to activate and inhibit angiogenetic signaling in BDL rat model, respectively, to verify the crucial function of lymphangiogenesis in the development of liver cirrhosis and portal hypertension (PHT). In clinical practice, platelet transfusion has been applied to improve liver function in patients suffering from chronic liver disease and cirrhosis. Therefore, this study provides support for the application of platelet transfusion or pharmacological intervention of lymphangiogenesis as novel therapeutic approaches for liver cirrhosis and PHT.©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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大类 | 3 区医学

小类 | 4 区胃肠肝病学

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第一作者机构： [1]Department of General Surgery, The First People's Hospital of Dali City, Dali 671000, Yunnan Province, China.

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