机构：[1]Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Yunnan University of Chinese Medicine, Kunming 650500, China.[2]The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, China.
Renifolin F is a prenylated chalcone isolated from Shuteria involucrata, a traditional minority ethnic medicine used to treat the respiratory diseases and asthma. Based on the effects of the original medicine plant, we established an in vivo mouse model of allergic asthma using ovalbumin (OVA) as an inducer to evaluate the therapeutic effects of Renifolin F. In the research, mice were sensitized and challenged with OVA to establish an allergic asthma model to evaluate the effects of Renifolin F on allergic asthma. The airway hyper-reactivity (AHR) to methacholine, cytokine levels, ILC2s quantity and mircoRNA-155 expression were assessed. We discovered that Renifolin F attenuated AHR and airway inflammation in the OVA-induced asthmatic mouse model by inhibiting the regulation of ILC2s in the lung, thereby, reducing the upstream inflammatory cytokines IL-25, IL-33 and TSLP; the downstream inflammatory cytokines IL-4, IL-5, IL-9 and IL-13 of ILC2s; and the co-stimulatory factors IL-2 and IL-7; as well as the expression of microRNA-155 in the lung. The findings suggest a therapeutic potential of Renifolin F on OVA-induced airway inflammation.
基金：
This research was funded by the National Natural Science Foundation of China (grant
number 81960778, 82060751), the Middle-Aged Academic and Technical Leaders of Yunnan Province
(grant number 202205AC160039), the Yunnan Provincial Science and Technology Department-Applied
Basic Research Joint Special Funds of Chinese Medicine (grant number 2019FF002-009), the Key project
of Yunnan provincial science and technology department (grant number 2019FA035) and the Yunnan
Innovation Team of Application Research on TCM Theory of Prevention Disease at Yunnan University
of TCM (grant number 2017HC011).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区化学
小类|3 区化学：综合3 区生化与分子生物学
最新[2023]版：
大类|2 区化学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者机构：[1]Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Yunnan University of Chinese Medicine, Kunming 650500, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Zhuya,Li Xiaohong,Fu Rongbing,et al.Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo[J].Molecules (Basel, Switzerland).2022,27(12):doi:10.3390/molecules27123789.
APA：
Yang Zhuya,Li Xiaohong,Fu Rongbing,Hu Min,Wei Yijie...&Huang Feng.(2022).Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo.Molecules (Basel, Switzerland),27,(12)
MLA：
Yang Zhuya,et al."Therapeutic Effect of Renifolin F on Airway Allergy in an Ovalbumin-Induced Asthma Mouse Model In Vivo".Molecules (Basel, Switzerland) 27..12(2022)
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