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MDSCs might be "Achilles heel" for eradicating CSCs

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机构： [1]Department of Pain Treatment, Tangdu Hospital, Air Force Military Medical University, Xi’an 710032, China [2]Department of General Surgery, The 75th Group Army Hospital, Dali 671000, China [3]Department of Stomatology, Shaanxi Provincial Hospital, Xi’an, Shaanxi 710038, China [4]Department of Anesthesiology, the 920 Hospital of Joint Logistic Support Force of Chinese PLA, Kunming, Yunnan, China [5]Department of Gynaecology and Obstetrics, The 75th Group Army Hospital, Dali 671000, China [6]Department of Anorectal Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China [7]Department of Intervention Therapy, The Second Affiliated Hospital, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China

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关键词： MDSCs Cancer stem cells Tumor progression Cancer plasticity Cytokines

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During tumor initiation and progression, the complicated role of immune cells in the tumor immune microenvironment remains a concern. Myeloid-derived suppressor cells (MDSCs) are a group of immune cells that originate from the bone marrow and have immunosuppressive potency in various diseases, including cancer. In recent years, the key role of cancer stemness has received increasing attention in cancer development and therapy. Several studies have demonstrated the important regulatory relationship between MDSCs and cancer stem cells (CSCs). However, there is still no clear understanding regarding the complex interacting regulation of tumor malignancy, and current research progress is limited. In this review, we summarize the complicated role of MDSCs in the modulation of cancer stemness, evaluate the mechanism of the relationship between CSCs and MDSCs, and discuss potential strategies for eradicating CSCs with respect to MDSCs.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2022]版中科院分区表Review为是的期刊

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大类 | 2 区医学

小类 | 2 区生化与分子生物学 3 区细胞生物学

最新[2023]版

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大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区细胞生物学

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第一作者机构： [1]Department of Pain Treatment, Tangdu Hospital, Air Force Military Medical University, Xi’an 710032, China

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通讯机构： [1]Department of Pain Treatment, Tangdu Hospital, Air Force Military Medical University, Xi’an 710032, China [7]Department of Intervention Therapy, The Second Affiliated Hospital, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China [*1]Tangdu Hospital, Air Force Military Medical University, Xi’an 710032, China.

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