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Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis

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机构： [1]Department of Oncology, Dongguan People's Hospital, Southern Medical University, Dongguan, China. [2]Clinical Research Center, Dongguan People's Hospital, Southern Medical University, Dongguan, China. [3]Department of Galactophore, Dongguan People's Hospital, Southern Medical University, Dongguan, China. [4]Department of Pathology, Dongguan People's Hospital, Southern Medical University, Dongguan, China. [5]Department of Reproductive Medicine, The First Affiliated Hospital of Dali University, Dali, Yunnan, China

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关键词： X inactive specific transcript Breast cancer miRNA-155 Caudal-type homeobox 1

摘要：

Long non-coding RNA (lncRNA) is an important member of non-coding RNA family and emerging evidence has indicated that it plays a pivotal role in many physiological and pathological processes. The lncRNA X inactive specific transcript (XIST) is a potential tumour suppressor in some types of cancers. However, the expression and function of XIST in breast cancer remain largely unclear. The objective of this study was to evaluate the expression and biological role of XIST in breast cancer. The results showed that XIST was significantly down-regulated in breast cancer tissues and cell lines. Further functional analysis indicated that overexpression of XIST remarkably inhibited breast cancer cell growth, migration, and invasion. The results of luciferase reporter assays verified that miR-155 was a direct target of XIST in breast cancer. Moreover, caudal-type homeobox 1 (CDX1) was identified as a direct target of miR-155 and miR-155/CDX1 rescued the effects of XIST in breast cancer cells. Taken together, our results suggest that XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR-155/CDX1 axis.Copyright © 2018. Published by Elsevier Inc.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

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第一作者机构： [1]Department of Oncology, Dongguan People's Hospital, Southern Medical University, Dongguan, China.

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通讯机构： [4]Department of Pathology, Dongguan People's Hospital, Southern Medical University, Dongguan, China. [*1]Wandao Road(south), Xinguyong Village, Wanjiang District, Dongguan City, Guangdong province, 523000, China

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