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Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway

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资源类型：
Pubmed体系：
作者：
Li Kejia[1,2] * ; Zhang Xiaochao[1] * ; He Bo[1] ; Yang Renhua[1] ; Zhang Yue[1] ; Shen Zhiqiang[1] ; Chen Peng[1] ; Du Wei[3] ;
机构： [1]School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 1168 West Chunrong Road, Kunming, Yunnan 650500, China [2]Department of Pharmacy, The Second Affiliated Hospital of Kunming Medical University, 374 Dianmian Avenue, Kunming, Yunnan 650101, China [3]Department of Radiology, The First Affiliated Hospital of Dali University, 32 Carlsberg Avenue, Dali, Yunnan 671000, China
出处：
DOI： 10.1016/j.biopha.2018.01.040
ISSN：

关键词： Geraniin Osteogenesis Osteoblastic differentiation Wnt/β-catenin pathway

摘要：
Geraniin is an ellagitannin isolated from Phyllanthus amarus and has a wide range of bioactivities. Our previous study demonstrated that geraniin could alleviate osteoporosis by accelerating bone formation, but the mechanism remains unclear. This study aimed to elucidate the molecular mechanisms by which geraniin promotes osteoblast proliferation and differentiation in vitro. Primary rat bone marrow-derived mesenchymal stem cells were separated and divided into sham operated (Sham) group, Sham treated with geraniin (Sham + GE) group, ovariectomized (OVX) group, OVX treated with geraniin (OVX + GE) group, OVX treated with osteogenic medium (OVX + OM) group, OVX treated with Wnt inhibitor (OVX + WI) group, and OVX treated with Wnt inhibitor and geraniin (OVX + W I + GE) group. Following bilateral ovariectomy, the expression of β-catenin, frizzled2, LRP6, TCF4, LEF1, c-myc, cyclin D1, Runx2 and osterix significantly reduced, while the expression of axin2 significantly increased (P < 0.05). Geraniin enhanced the expression of β-catenin, frizzled2, LRP6, TCF4, LEF1, c-myc, cyclin D1, Runx2 and osterix, while inhibited the expression of axin2 (P < 0.05). Wnt inhibitor significantly weakened geraniin-induced Wnt/β-catenin activation (P < 0.05). In conclusion, geraniin enhances the activation of Wnt/β-catenin pathway, which may explain how it promotes osteoblast proliferation and differentiation.Copyright © 2018 Elsevier Masson SAS. All rights reserved.

基金：
National Natural Science Foundation of China (Grant: 81160401, 81260493, 81660613), and the Natural Science Foundation of Yunnan Province, China (Grant: 2013FB103, 2015FA021, 2017FB139, 2017FE467).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 1 区 药学 2 区 医学：研究与实验
第一作者：
第一作者机构： [1]School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 1168 West Chunrong Road, Kunming, Yunnan 650500, China [2]Department of Pharmacy, The Second Affiliated Hospital of Kunming Medical University, 374 Dianmian Avenue, Kunming, Yunnan 650101, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Kejia,Zhang Xiaochao,He Bo,et al.Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway[J].BIOMEDICINE & PHARMACOTHERAPY.2018,99:319-324.doi:10.1016/j.biopha.2018.01.040.
APA：
Li Kejia,Zhang Xiaochao,He Bo,Yang Renhua,Zhang Yue...&Du Wei.(2018).Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway.BIOMEDICINE & PHARMACOTHERAPY,99,
MLA：
Li Kejia,et al."Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway".BIOMEDICINE & PHARMACOTHERAPY 99.(2018):319-324

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