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Design, synthesis and anticancer activity of novel hybrid compounds between benzofuran and N-aryl piperazine

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机构： [1]School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China [2]Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, PR China

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关键词： Benzofuran N-Aryl piperazine Hybrid compounds Anticancer activity

摘要：

A series of novel hybrid compounds between benzofuran and N-aryl piperazine have been designed and prepared. These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines by MTT assay. The results demonstrated that amide derivatives were more bioactive than sulfonamide compounds in general, and that chloro or trifluoromethyl substituent was vital for modulating cytotoxic activity. In particular, compound 13 was found to be the most potent compound against 4 strains human tumor cell lines, and exhibited cytotoxic activity selectively against Hela (0.03μM).Copyright © 2016 Elsevier Ltd. All rights reserved.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区有机化学

最新[2023]版：

大类 | 4 区医学

小类 | 2 区有机化学 4 区药物化学

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第一作者机构： [1]School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China

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Design, synthesis and anticancer activity of novel hybrid compounds between benzofuran and N-aryl piperazine

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