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Ethnic and geographic variations in HPV prevalence and genotype distribution in north-western Yunnan, China

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机构: [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. [2]Research Center for Molecular Medicine, Kunming, 650500, China. [3]First Hospital, Yunnan Province, Kunming, 650034, China. [4]Second Affiliated Hospital, Kunming Medical University, Kunming, 650101, China.
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关键词: HPV prevalence regional ethnic Shangri-le Lijiang northwestern Yunnan

摘要:
The prevalence and genotype distribution of human papillomavirus (HPV) vary throughout the world. To assess the prevalence and genotype distribution of HPV among three ethnic groups in two geographic locations in north-western Yunnan, we recruited 522 women in Shangri-le (n = 255) and Lijiang (n = 267). PCR amplification of HPV DNA was performed on cervical cells from these women using two consensus primer systems (MY09/11 and GP5/6). Amplified-HPV DNA was genotyped using the HPV GenoArray test. Geographically, the HPV prevalence was significantly higher (P = 0.002) among Shangri-le women than among Lijiang women. Infections with high-risk (HR)-HPV and with multiple HPV genotypes were also significantly more common (P = 0.001) among women in Shangri-le than women in Lijiang. Additionally, the prevalence of overall, HR-HPV, and single genotype HPV infections was significantly higher (P = 0.001) among Tibetan women than among Naxi and Han women. HPV-16 and HPV-33 were significantly more frequent in Shangri-le women compared with Lijiang (P = 0.006) women. In addition, HPV-16 (9.81%) and HPV-33 (5.88%) were significantly more prevalent in Tibetan women than in Naxi and Han women. Here, for the first time, we highlight the significant variation in the prevalence and genotype distribution of HPV in various populations in the north-western region of Yunnan Province.© 2015 Wiley Periodicals, Inc.

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出版当年[2016]版:
大类 | 3 区 医学
小类 | 4 区 病毒学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 病毒学
第一作者:
第一作者机构: [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. [2]Research Center for Molecular Medicine, Kunming, 650500, China.
通讯作者:
通讯机构: [1]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. [2]Research Center for Molecular Medicine, Kunming, 650500, China. [3]First Hospital, Yunnan Province, Kunming, 650034, China. [*1]First Hospital, Yunnan Province, Kunming 650034, China [*2]Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
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