机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, Science and Technology Affiliated Hospital, Kunming University, Kunming, China医技片输血科云南省第一人民医院[2]Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, China[3]Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, China[4]Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China[5]Department of Blood Transfusion, Second People’s Hospital, Kunming 650021, Yunnan Province, China
CYP2J2 is a sole member of the cytochrome P450 (CYP) 2J subfamily of monooxygenases, which metabolized lots of therapeutic agents and compounds. Detection of CYP2J2 variant alleles, and knowledge about their allelic frequency in Zhuang ethnic groups, is important to establish the clinical relevance of screening for these polymorphisms to optimize pharmacotherapy. We directly used DNA sequencing to investigate the promoter, exons and surrounding introns, and 3'-untranslated region of the CYP2J2 gene in 100 unrelated healthy Zhuang individuals and identified 16 different CYP2J2 polymorphisms in the Zhuang population, in which including one novel variants detected in intron 2 (59907828 C > T). And we determined the allele frequencies of CYP2J2*1 and CYP2J2*7 were 95.5% and 4.5%, respectively. Our results summarized related information on CYP2J2 polymorphisms in Zhuang individuals and provide new data about Zhuang populations to enrich the pharmacogenomic database.
基金：
Educational Department Scientific Research Key Fund of Engineering of Yunnan Province (2014Z038).
语种：
外文
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, Science and Technology Affiliated Hospital, Kunming University, Kunming, China
共同第一作者：
通讯作者：
通讯机构：[2]Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, China[3]Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, China[4]Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China[5]Department of Blood Transfusion, Second People’s Hospital, Kunming 650021, Yunnan Province, China[*1]Department of Blood Transfusion, Second People’s Hospital, Kunming 650021, Yunnan Province, China.[*2]Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, China .Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, China. Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet autonomous Region, School of Medicine, Xizang Minzu Uni-versity, Xianyang, Shaanxi, China.
推荐引用方式(GB/T 7714)：
Chan Zhang,Wanlu Chen,Qing Li,et al.Genetic polymorphism analysis of CYP2J2 drug-metabolizing enzyme in a Chinese Zhuang population[J].International Journal of Clinical and Experimental Pathology.2016,9(10):
APA：
Chan Zhang,Wanlu Chen,Qing Li,Xugang Shi,Ridong Xia...&Tianbo Jin.(2016).Genetic polymorphism analysis of CYP2J2 drug-metabolizing enzyme in a Chinese Zhuang population.International Journal of Clinical and Experimental Pathology,9,(10)
MLA：
Chan Zhang,et al."Genetic polymorphism analysis of CYP2J2 drug-metabolizing enzyme in a Chinese Zhuang population".International Journal of Clinical and Experimental Pathology 9..10(2016)
