Objective: In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island. Methods: We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0). Results: Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P<0.001. Further analysis implied that genotypes B1B1 (P<0.001, OR=0.148, 95% CI=0.095-0.230) and VV (P<0.001 and OR=0.353, 95% CI=0.237-0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P<0.001, OR=0.128, 95% CI=0.049-0.329), B1B1-IV (P<0.001, OR=0.115, 95% CI=0.056-0.237), B1B2-VV (P<0.05, OR=0.534, 95% CI=0.310-0.920), and B2B2-VV (P<0.001, OR=0.198, 95% CI=0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan. Conclusion: Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.
基金：
National Natural Science
Foundation of China (No. 31501018 and 81260510); Social
Development Project of Hainan Province (SF201401).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|4 区医学
小类|4 区公共卫生、环境卫生与职业卫生4 区热带医学
最新[2023]版：
大类|4 区医学
小类|4 区公共卫生、环境卫生与职业卫生4 区热带医学
JCR分区：
出版当年[2015]版：
Q3TROPICAL MEDICINEQ4PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2TROPICAL MEDICINEQ3PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Hainan Med Coll, Dept Biochem & Mol Biol, Haikou, Hainan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hainan Med Coll, Dept Biochem & Mol Biol, Haikou, Hainan, Peoples R China[*1]Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, Hainan Province, China.
推荐引用方式(GB/T 7714)：
Zhang Yun-Xia,Su Ya,Tang Li,et al.CETP polymorphism confer genetic contribution to centenarians of Hainan, south of China[J].ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE.2016,9(9):851-855.doi:10.1016/j.apjtm.2016.07.009.
APA：
Zhang, Yun-Xia,Su, Ya,Tang, Li,Yang, Ze-Xing,Zhou, Dai-Feng...&Cai, Wang-Wei.(2016).CETP polymorphism confer genetic contribution to centenarians of Hainan, south of China.ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE,9,(9)
MLA：
Zhang, Yun-Xia,et al."CETP polymorphism confer genetic contribution to centenarians of Hainan, south of China".ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE 9..9(2016):851-855
