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Chemical constituents from Aphanamixis grandifolia

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机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201 Yunnan, PR China [2]University of Chinese Academy of Sciences, Beijing 100039, PR China [3]Research Center of Natural Medicine, Clinical School of Kunming General Hospital of Chengdu Military Command, Kunming 650032, PR China

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关键词： Aphanamixis grandifolia 30 Diterpenoid 31 TDDFT 32 Nemoralisins D–G

摘要：

Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic diterpenoids, which are structurally related nemoralisin C and nemoralisin. These structures were established on the basis of spectroscopic methods and the absolute configuration of 1 was determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Nemoralisins D-G (1-4) were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines (IC50>40 μM), as well as the antimicrobial activities on Staphylococcus aureus, Pseudomonas aeruginosa, MRSA92(#) and MRSA98(#) (MIC>50 μg/mL).Copyright © 2013 Elsevier B.V. All rights reserved.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区药物化学 4 区药学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

第一作者：

第一作者机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201 Yunnan, PR China [2]University of Chinese Academy of Sciences, Beijing 100039, PR China

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Chemical constituents from Aphanamixis grandifolia

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