机构：[1]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041四川大学华西医院[2]Department of Radiology, The First People's Hospital of Chengdu, Chengdu, Sichuan 610095[3]Kunming University School of Medicine, Kunming University School, Kunming, Yunnan 650124, P.R. China
T‑cell/transmembrane immunoglobulin and mucin domain containing 4 (TIM‑4) is a phosphatidylserine receptor that is mainly expressed on antigen‑presenting cells and is involved in the recognition and efferocytosis of apoptotic cells. TIM‑4 has been found to be expressed in immune cells such as natural killer T, B and mast cells and to participate in multiple aspects of immune regulation, suggesting that TIM‑4 may be involved in a variety of immune‑related diseases. Recent studies have confirmed that TIM‑4 is also abnormally expressed in a variety of malignant tumor cells and is closely associated with the occurrence and development of tumors and the tumor immune microenvironment. The present study aimed to describe the expression and functional characteristics of TIM‑4 in detail and to comprehensively discuss its role in pathophysiological processes such as infection, allergy, metabolism, autoimmunity and tumor immunity. The current review provided a comprehensive understanding of the functions and characteristics of TIM‑4, as well as novel ideas for the diagnosis and treatment of diseases.
基金：
This study was funded by West China Hospital Clinical
Research Incubation Project (approval no. 21HXFH058),
the 1·3·5 Project for Disciplines of Excellence‑Clinical
Research Incubation Project (approval no. ZYJC21037),
West China Hospital, Sichuan University; Science and
Technology Planning Project of Yunnan Province Science and
Technology Department (approval no. 202001BA070001‑191)
and Scientific Research Fund Project of Yunnan Province
Education Department (approval no. 2019J0567).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|3 区医学：研究与实验
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041[*1]Department of Pancreatic Surgery, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
Wang Ziyao,Chen Chen,Su Yingzhen,et al.Function and characteristics of TIM‑4 in immune regulation and disease (Review)[J].International journal of molecular medicine.2023,51(2):doi:10.3892/ijmm.2022.5213.
APA：
Wang Ziyao,Chen Chen,Su Yingzhen&Ke Nengwen.(2023).Function and characteristics of TIM‑4 in immune regulation and disease (Review).International journal of molecular medicine,51,(2)
MLA：
Wang Ziyao,et al."Function and characteristics of TIM‑4 in immune regulation and disease (Review)".International journal of molecular medicine 51..2(2023)
