机构：[1]Department of Oncology, Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha 410006, Changsha, China.[2]Department of Thoracic Surgery, The First People's Hospital Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034, Yunnan, China.外科片胸外科云南省第一人民医院[3]Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, Chongqing, China.重庆医科大学附属第一医院[4]Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan, China.[5]Department of Cardiothoracic Surgery, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034, Yunnan, China.外科片胸外科云南省第一人民医院[6]Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.[7]College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.[8]Department of Internal Medicine, College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa 410006, Macau, China.
Long noncoding RNAs (lncRNAs) reportedly play critical roles in the pathogenesis of various cancers, including lung adenocarcinoma (LUAD). However, the expression level, clinical significance, and potential function of lncRNA-AC092718.4 in LUAD remain unclear. In this study, we found that AC092718.4 was highly expressed in LUAD and high expression of AC092718.4 was correlated with poor overall survival (OS) and disease-specific survival (DSS) in LUAD. Cox regression analysis confirmed that AC092718.4 was an independent factor for LUAD prognosis. Kyoto Encyclopedia of Genes and Genomes (KEGG) results showed that AC092718.4 was involved in the PI3K-Akt signaling pathway, Th17 cell differentiation, and cell apoptosis. AC092718.4 expression was correlated with immune cell infiltration. Finally, we found that the knockdown of AC092718.4 inhibited lung adenocarcinoma (LUAD) cell growth and promote cell apoptosis. Our findings confirmed that AC092718.4 may serve as a potential prognostic biomarker in LUAD.
基金：
This work was supported by Yunnan Fundamental
Research Projects (grant NO. 202101AS070043),
Kunming Science and Technology Plan Project (grant
NO. 2020-1-H-003).
The First People’s Hospital of Yunnan Province
Clinical Medicine Center Opening Project (grant
2021LCZXXF-XB3. Chinese Medicine Scientific Research Program of Hunan Province (2021235),
according to Hunan Province Natural Science
Foundation (2021JJ40405), and Excellent Youth
Program of Hunan Provincial Education Department
(21B0384); Hunan Provincial Health Commission
Project (B202319017574).
第一作者机构：[1]Department of Oncology, Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha 410006, Changsha, China.
共同第一作者：
通讯作者：
通讯机构：[5]Department of Cardiothoracic Surgery, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034, Yunnan, China.[6]Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
推荐引用方式(GB/T 7714)：
Chen Siqin,Yu Yang,Yuan Yixiao,et al.A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression[J].AGING-US.2022,14(24):9924-9941.doi:10.18632/aging.204426.
APA：
Chen Siqin,Yu Yang,Yuan Yixiao,Chen Xi,Zhou Fan...&Ren Wenjun.(2022).A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression.AGING-US,14,(24)
MLA：
Chen Siqin,et al."A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression".AGING-US 14..24(2022):9924-9941
