To organize the fragmented information available in the literature to describe and summarize the extracts used by natural medicines in the treatment of bone loss, and to provide evidence and support for the potential use of natural medicines in the treatment of osteoporosis.A literature survey for relevant information regarding the osteogenesis of Dongkuiguo (), Machixian (). etc., was conducted using PubMed, ScienceDirect, MEDLINE, Springer LINK and Google Scholar electronic databases from the years 2000-2020.Dongkuiguo (), Machixian (). etc., both inhibit the activity of osteoclasts and reduce bone resorption by regulation of signaling pathways through interacting with signaling molecules.In this review, the current knowledge of the novel medicines with osteogenesis properties were summarized and their potential in the treatment of bone loss were demonstrated, but the lack of research on the regulation of the signaling pathway's mechanism of action, and the corresponding theoretical basis for the application of natural medicines in clinical osteoporosis, made it difficult to be widely applied and promoted in clinical practice. Further experiments with some of the medicines and the mechanisms is needed to realize their potential as osteoporosis treatments.