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Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990-2017

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机构： [1]School of Public Health, Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China, [2]Division of Sleep Medicine, Peking University People’s Hospital, Beijing, China, [3]Department of Pulmonary Medicine, Beijing Children’s Hospital, Beijing, China, [4]Department of Neurology, Shanghai Changzheng Hospital, Shanghai, China, [5]Sleep and Wake Disorders’ Center of Fudan University, Neurology Department of Huashan Hospital, Fudan University, National Center for Neurological Disorders, Shanghai, China, [6]Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China, [7]Department of Neurology, First Bethune Hospital of Jilin University, Changchun, Jilin, China, [8]The Sleep Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China, [9]The Sleep Center, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China, [10]The Sleep Center, Shantou University Mental Health Center, Shantou, Guangdong, China, [11]The Sleep Center, Guang’anmen Hospital, Beijing, China, [12]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China, [13]The Sleep Center, Qinghai Red Cross Hospital, Xining, Qinghai, China, [14]Department of Psychiatry, Xiamen Xianyue Hospital, Xiamen, Fujian, China, [15]Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China, [16]Department of Child Psychiatry, Chang Gung Memorial University Hospital, Tao-Yuan, Taipei, Taiwan, [17]Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China, [18]Department of Neurology, Peking University People’s Hospital, Beijing, China, [19]Department of Psychiatry and Behavioral Sciences, Stanford University Center for Sleep Sciences and Medicine, Palo Alto, CA, USA, [20]Department of Infectious Diseases, Huashan Hospital, School of Public Health, Fudan University, Shanghai, China, [21]Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China and [22]Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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关键词： narcolepsy epidemiology 2009 H1N1 pandemic

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Increased incidence of narcolepsy was reported in children during the 2009 H1N1 pandemic following Pandemrix®, a H1N1 flu vaccine. A link with A(H1N1)pdm09 infections remains controversial. Using nationwide surveillance data from China (1990 to 2017), the epidemiology of narcolepsy was analyzed.Individual records of narcolepsy patients were collected from 15 of 42 hospitals across China known to diagnose cases. Incidence was estimated assuming representativeness of these hospitals. Age-specific incidence, epidemiological and clinical characteristics of patients were evaluated before, during, and after the 2009 H1N1 pandemic. Sensitivity analyses were conducted by including NT1 cases only and to exclude the effect of 2009 H1N1 vaccination.Average annual incidence was 0.79 per 100,000 person-years (PY) from 1990 to 2017 and 1.08 per 100,000 PY from 2003 to 2017. Incidence increased 4.17 (95%CI 4.12, 4.22) and 1.42 (95%CI 1.41, 1.44) fold during and after the 2009 H1N1 pandemic when compared to baseline. These results were robust in sensitivity analyses. Patients with onset of narcolepsy during the pandemic period were younger (notably in 5-9-year-old strata), and age shift toward younger children reversed to baseline following the pandemic.Increased incidence of narcolepsy was observed during the 2009 H1N1 pandemic period. This is likely to be associated with the circulation of the wild-type A(H1N1)pdm09 virus. This observation should be considered for future influenza pandemic preparedness plans.© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

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Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 5.3 最新[2023版] 5.7 最新五年平均 5.6 出版当年[2022版] 6 出版当年五年平均 6.313 出版前一年[2021版] 5.3 出版后一年[2023版]

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第一作者机构： [1]School of Public Health, Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China,

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通讯机构： [2]Division of Sleep Medicine, Peking University People’s Hospital, Beijing, China, [20]Department of Infectious Diseases, Huashan Hospital, School of Public Health, Fudan University, Shanghai, China, [21]Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China and [22]Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China [*1]Department of Infectious Diseases, Huashan Hospital, School of Public Health, Fudan University, No. 130 Dong’an Road, Shanghai 200032, China. [*2]Division of Sleep Medicine, Peking University People’s Hospital, Xi Cheng Qu, Beijing 100044, China.

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Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990-2017

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