Comparison of uterine, endometrial and subendometrial blood flows in predicting pregnancy outcomes between fresh and frozen-thawed embryo transfer after GnRH antagonist protocol: a retrospective cohort study
机构：[1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China门急诊片生殖医学科云南省第一人民医院[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China云南省第一人民医院[3]NHC Key Laboratory of Periconception Health Birth in Western China, Kunming, Yunnan, China
This retrospective cohort study aimed to compare endometrial receptivity and pregnancy rate between fresh embryo transfer (ET) and frozen-thawed ET after gonadotrophin-releasing hormone (GnRH) antagonist protocol in normal ovarian responders. The patients were divided into two groups: the fresh ET group and the frozen-thawed ET group. Uterine artery resistance index (RI) and endometrial thickness were lower in the frozen-thawed ET group. The proportion of detectable endometrial-subendometrial flow was significantly higher in the frozen-thawed ET group. There was no significant difference in miscarriage rate between the two groups. Frozen-thawed ET group had a significantly higher CPR (56.0% vs. 48.1%), implantation rate (32.2% vs. 26.4%), and LBR (45.4% vs. 36.5%) than the fresh ET group. In GnRH antagonist protocol, elective frozen-thawed ET should be ideally taken, as this could improve embryo implantation rate, clinical pregnancy rate, and live birth rate, thus presenting an effective strategy to enhance the embryo utilization rate. IMPACT STATEMENT What is already known on this subject? The clinical pregnancy rate following fresh embryo transfer (ET) was lower than frozen-thawed ET after GnRH antagonist protocol. IVF success depends on embryo quality, embryo-endometrium interaction and endometrial receptivity. A good blood supply toward the endometrium is generally considered a requirement for implantation. What do the results of this study add? Uterine artery RI and endometrial thickness were significantly lower in the frozen-thawed ET group. The proportion of detectable endometrial-subendometrial flow was significantly higher in the frozen-thawed ET group. Frozen-thawed ET group had a significantly higher clinical pregnancy rate, implantation rate and live birth rate than the fresh ET group after GnRH antagonist protocol. What are the implications of these findings for clinical practice and/or further research? In GnRH antagonist protocol, elective frozen-thawed ET should be ideally taken, as this could improve embryo implantation rate, clinical pregnancy rate and live birth rate, thus presenting an effective strategy to enhance the embryo utilization rate.
基金：
This work was supported by grants from the Yunnan Provincial Reproductive and Obstetrics and Gynaecology Clinical Medicine Centre (zx2019-01-01), Open Project of Yunnan Provincial Reproductive and Obstetrics and Gynaecology Clinical Medicine Centre (2020LCZXKF-SZ15, 2020LCZXKF-SZ07, 2020LCZXKF-SZ14, 2020LCZXKF-SZ08, 2020LCZXKF- SZ11) and Innovation Research Project of Human Assisted Reproductive Technology of Yunnan Province(2017HC009).
第一作者机构：[1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China[3]NHC Key Laboratory of Periconception Health Birth in Western China, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China[3]NHC Key Laboratory of Periconception Health Birth in Western China, Kunming, Yunnan, China[*1]Department of Reproductive Medicine, The First People’s Hospital of Yunnan Province, Kunming, China
推荐引用方式(GB/T 7714)：
Yu Jianmei,Li Bo,Li Haiyan,et al.Comparison of uterine, endometrial and subendometrial blood flows in predicting pregnancy outcomes between fresh and frozen-thawed embryo transfer after GnRH antagonist protocol: a retrospective cohort study[J].JOURNAL OF OBSTETRICS AND GYNAECOLOGY.2023,43(1):doi:10.1080/01443615.2023.2195937.
APA：
Yu, Jianmei,Li, Bo,Li, Haiyan,Li, Qing,Nai, Zhen...&Li, Yunxiu.(2023).Comparison of uterine, endometrial and subendometrial blood flows in predicting pregnancy outcomes between fresh and frozen-thawed embryo transfer after GnRH antagonist protocol: a retrospective cohort study.JOURNAL OF OBSTETRICS AND GYNAECOLOGY,43,(1)
MLA：
Yu, Jianmei,et al."Comparison of uterine, endometrial and subendometrial blood flows in predicting pregnancy outcomes between fresh and frozen-thawed embryo transfer after GnRH antagonist protocol: a retrospective cohort study".JOURNAL OF OBSTETRICS AND GYNAECOLOGY 43..1(2023)
