Thicker endometrium on hCG trigger day improves the live birth rate of fresh cleavage embryo transfer in GnRH-agonist regimen of normogonadotrophic women
Background: Luteinizing hormone (LH) and progesterone (PROG) on human chorionic gonadotropin (hCG) trigger day are significantly correlated with assisted reproductive technology (ART) outcome. Moreover, LH and PROG are also involved in the functional preparation of the endometrium during the implantation window; however, whether they are related to endometrial thickness (EMT) is still unknown. The aim of the present study was to assess whether EMT has a positive correlation on the live birth rate following fresh embryo transfer (ET), and whether LH and PROG have an impact on EMT. Methods: A total of 2,260 normogonadotrophic women were treated with a GnRH agonist for in vitro fertilization (IVF)/intracytoplasmic sperm injection. Patients with advanced age and poor ovarian reserve were excluded. The levels of LH, PROG, and EMT on the hCG trigger day were divided into binary variables, respectively, by the cutoff values, and which were obtained based on receiver operating characteristic curve analysis of live birth among LH, PROG and EMT levels on the hCG trigger day, respectively. Multivariate binary logistic regression was used to confirm the role of LH, PROG, and EMT on the live birth, and stratified analysis was used to determine whether LH and PROG have an impact on EMT. Results: EMT and LH were protective factors for live births, with odds ratios (OR) of 1.11 [95% confidence interval (CI): 1.066 & ndash;1.157] and 1.696 (95% CI: 1.345 & ndash;2.139), respectively. However, PROG was a risk factor for live birth, with an OR of 0.635 (95% CI: 0.526 & ndash;0.766). The hierarchical cross-table analysis indicated that EMT had no significant difference for live birth in the combination of low LH and high PROG group. In the other subgroups, thick EMT was associated with a higher live birth rate (P<0.05). Conclusions: On hCG trigger day, EMT, LH, and PROG all were independent factors that affected the live birth of fresh ETs. Thick EMT can significantly increase the live birth rate. However, multivariate logistic regression analysis showed that EMT does not affect the live birth rate in combination of low LH and high PROG environment.
基金：
National Key Research and Development Program (Grant No. 2018YFC1002106), Program of Application and Fundamental Research of the Joint Special Project of Yunnan Provincial Science Technology Department & Kunming Medical University [Grant No. 2018FE001(-302)], Open Project of Yunnan Provincial Reproductive and Obstetrics and Gynecology Clinical Medicine Center (Grant No. 2019LCZXKF-SZ01), Key Projects of Basic and Applied Research in Yunnan Province (Grant No. 2018FA009), Yunnan Academic Leaders and Reserve Personnel (Grant No. 2017HB041), Medical Academic Leaders Training Program of Yunnan Province (D-2017022), Program of Application and Fundamental Research of the Joint Special Project of Yunnan Provincial Science Technology Department & Kunming Medical University [Grant No. 2018FE001(-120)], and the Yunnan Provincial Reproductive and Obstetrics and Gynecology Clinical Medicine Center (Grant No. zx2019-01-01).
第一作者机构：[1]First Peoples Hosp Yunnan Prov, Dept Reprod Med, 157 Jinbi Rd, Kunming 650032, Yunnan, Peoples R China[2]Kunming Univ Sci & Technol, Affiliated Hosp, Reprod Med Ctr Yunnan Prov, Kunming, Yunnan, Peoples R China[3]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China[4]Kunming Univ Sci & Technol, Sch Med, Kunming, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]First Peoples Hosp Yunnan Prov, Dept Reprod Med, 157 Jinbi Rd, Kunming 650032, Yunnan, Peoples R China[2]Kunming Univ Sci & Technol, Affiliated Hosp, Reprod Med Ctr Yunnan Prov, Kunming, Yunnan, Peoples R China[*1]Department of Reproductive Medicine, the First People’s Hospital of Yunnan Province, No 157 Jinbi Rd, Kunming 650032, China
推荐引用方式(GB/T 7714)：
Luo Xi,Li Yunxiu,Zheng Haishan,et al.Thicker endometrium on hCG trigger day improves the live birth rate of fresh cleavage embryo transfer in GnRH-agonist regimen of normogonadotrophic women[J].ANNALS OF TRANSLATIONAL MEDICINE.2021,9(10):doi:10.21037/atm-21-1922.
APA：
Luo, Xi,Li, Yunxiu,Zheng, Haishan,Ding, Lei,Zhang, Manqin...&Wu, Ze.(2021).Thicker endometrium on hCG trigger day improves the live birth rate of fresh cleavage embryo transfer in GnRH-agonist regimen of normogonadotrophic women.ANNALS OF TRANSLATIONAL MEDICINE,9,(10)
MLA：
Luo, Xi,et al."Thicker endometrium on hCG trigger day improves the live birth rate of fresh cleavage embryo transfer in GnRH-agonist regimen of normogonadotrophic women".ANNALS OF TRANSLATIONAL MEDICINE 9..10(2021)
