机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming, PR China[2]Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China[3]Qujing Maternal and Child Health-care Hospital Affiliated Hospital of Kunming University of Science and Technology, Qujing, PR China[4]Yunnan Provincial Key Laboratory of Clinical Virology, Kunming, PR China
Background: Hepatitis E virus (HEV) infection in pregnant women causes adverse pregnancy outcomes, including maternal death, premature delivery, stillbirth, and fetal infection. However, the pathogenesis of maternal and fetal HEV infection is unclear.Methods: Placenta and placental appendixes were collected from HEV-4 infected pregnant women to explore the vertical transmission of HEV from mothers to fetuses. Results: HEV-4 replicated in the placenta, placental membrane, and umbilical cord and was vertically transmitted from mothers to fetuses. HEV-4 placental infection resulted in serious histopathological damage, such as fibrosis and calcification, and severe inflammatory responses. Adverse maternal outcomes were observed in 38.5% of HEV-4 infected pregnant women. The distinct cytokine/chemokine expression patterns of HEV-infected pregnant women and nonpregnant women may contribute to the adverse pregnancy outcomes. Furthermore, the impaired maternal and fetal innate immune responses against HEV-4 facilitated viral replication during pregnancy. Conclusion: HEV-4 replicates in the placenta and is vertically transmitted from mothers to fetuses, causing severe histopathological damage.& COPY; 2023 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of China [82260396, 81960370]; Natural Science Foundation for Distinguished Young Scholars of Yunnan Province [202001AV070005]; Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province; Yunnan Provincial Key Laboratory of Clinical Virology [202205AG070053-01]; Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2021-I2M-1-024]; Program for Cultivating Reserve Talents in Medical Disciplines from the Health Committee of Yunnan Province [H-2019043]; Technical Innovation talents of Yunnan Province [202205AD160008]
第一作者机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Medical Faculty, Kunming University of Science and Technology, Kunming, PR China[4]Yunnan Provincial Key Laboratory of Clinical Virology, Kunming, PR China[*1]Medical School of Kunming University of Science and Technology, Kunming, Yunnan Province, PR China
推荐引用方式(GB/T 7714)：
Qian Zhongyao,Li Tengyuan,Xia Yueping,et al.Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses[J].JOURNAL OF INFECTION.2023,87(1):34-45.doi:10.1016/j.jinf.2023.05.003.
APA：
Qian, Zhongyao,Li, Tengyuan,Xia, Yueping,Cong, Chao,Chen, Shuangfeng...&Huang, Fen.(2023).Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses.JOURNAL OF INFECTION,87,(1)
MLA：
Qian, Zhongyao,et al."Genotype 4 Hepatitis E virus replicates in the placenta, causes severe histopathological damage, and vertically transmits to fetuses".JOURNAL OF INFECTION 87..1(2023):34-45
医学