机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032 Kunming, Yunnan, China医技片输血科云南省第一人民医院
Phosphodiesterase 4D interacting protein (PDE4DIP) interacts with cAMP-specific phosphodiesterase 4D and its abnormal expression promotes the development of hematological malignancies, breast cancer, and pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis of the association between PDE4DIP and various cancers. Thus, this study aimed to elucidate the potential functions of PDE4DIP in various cancers. Based on the multiple public databases and online websites, we conducted comprehensive analyses for PDE4DIP in various cancers, including differential expression, prognosis, genetic variation, DNA methylation, and immunity. We thoroughly analyzed the specific role of PDE4DIP in acute myeloid leukemia (LAML). The results indicated that there were differences in PDE4DIP expression in cancers, and in kidney chromophobe, LAML, pheochromocytoma and paraganglioma, thymoma, and uveal melanoma, PDE4DIP had potential prognostic value. PDE4DIP expression was also correlated with genetic variation, DNA methylation, immune cell infiltration, and immune-related genes in cancers. Functional enrichment analysis showed that PDE4DIP was mainly related to immune-related pathways in cancers, and in LAML, PDE4DIP was mainly related to immunoglobulin complexes, T-cell receptor complexes, and immune response regulatory signaling pathways. Our study systematically revealed for the first time the potential prognostic and immunotherapeutic value of PDE4DIP in various cancers, including LAML.
基金：
Special project of
Kunming Medical Association (202001AY070001-111, 2017FE468
(−125)), Open Project of Yunnan Clinical Medical Center
(2021LCZXXF-XY12, 2022LCZXKF-XY04), CAMS Innovation
Fund for Medical Sciences (CIFMS) (2016-12M-3-024), and Kunming University of Science and Technology – The
First People’s Hospital of Yunnan Province (The Affiliated
Hospital of Kunming University of Science and Technology)
Medical Joint Project (KUST-KH2022028Y).
第一作者机构：[1]Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032 Kunming, Yunnan, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Qi,Cheng Yujing,Chen Wanlu,et al.Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia[J].OPEN MEDICINE.2023,18(1):doi:10.1515/med-2023-0782.
APA：
Li, Qi,Cheng, Yujing,Chen, Wanlu,Wang, Ying,Dai, Run&Yang, Xin.(2023).Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia.OPEN MEDICINE,18,(1)
MLA：
Li, Qi,et al."Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia".OPEN MEDICINE 18..1(2023)
