Background Tumor deposits (TDs) are associated with poor prognosis in rectal cancer (RC). This study aims to develop and validate a deep learning (DL) model incorporating T2-MR image and clinical factors for the preoperative prediction of TDs in RC patients.Methods and methodsA total of 327 RC patients with pathologically confirmed TDs status from January 2016 to December 2019 were retrospectively recruited, and the T2-MR images and clinical variables were collected. Patients were randomly split into a development dataset (n = 246) and an independent testing dataset (n = 81). A single-channel DL model, a multi-channel DL model, a hybrid DL model, and a clinical model were constructed. The performance of these predictive models was assessed by using receiver operating characteristics (ROC) analysis and decision curve analysis (DCA).Results The areas under the curves (AUCs) of the clinical, single-DL, multi-DL, and hybrid-DL models were 0.734 (95% CI, 0.674-0.788), 0.710 (95% CI, 0.649-0.766), 0.767 (95% CI, 0.710-0.819), and 0.857 (95% CI, 0.807-0.898) in the development dataset. The AUC of the hybrid-DL model was significantly higher than the single-DL and multi-DL models (both p < 0.001) in the development dataset, and the single-DL model (p = 0.028) in the testing dataset. Decision curve analysis demonstrated the hybrid-DL model had higher net benefit than other models across the majority range of threshold probabilities.Conclusions The proposed hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer.
基金：
This study received funding from the Hospital-level Scientific Research Foundation
of Qujing First People’s Hospital (Grant No. YJKTZ04) and the Scientific
Research Fund of the Education Department of Yunnan Province (Grant No.
2023Y0700).
第一作者机构：[1]Qujing First Peoples Hosp, Dept Med Imaging Ctr, Qujing 655000, Yunnan, Peoples R China[2]Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Qujing First Peoples Hosp, Dept Med Imaging Ctr, Qujing 655000, Yunnan, Peoples R China[2]Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China[5]Sichuan Univ, West China Hosp, Funct & Mol Imaging Key Lab Sichuan Prov, Chengdu 610041, Sichuan, Peoples R China[6]Sanya Peoples Hosp, Dept Radiol, Sanya 572000, Hainan, Peoples R China
推荐引用方式(GB/T 7714)：
Jin Yumei,Yin Hongkun,Zhang Huiling,et al.Predicting tumor deposits in rectal cancer: a combined deep learning model using T2-MR imaging and clinical features[J].INSIGHTS INTO IMAGING.2023,14(1):doi:10.1186/s13244-023-01564-w.
APA：
Jin, Yumei,Yin, Hongkun,Zhang, Huiling,Wang, Yewu,Liu, Shengmei...&Song, Bin.(2023).Predicting tumor deposits in rectal cancer: a combined deep learning model using T2-MR imaging and clinical features.INSIGHTS INTO IMAGING,14,(1)
MLA：
Jin, Yumei,et al."Predicting tumor deposits in rectal cancer: a combined deep learning model using T2-MR imaging and clinical features".INSIGHTS INTO IMAGING 14..1(2023)
