The traditional view posits that bones and muscles interact primarily through mechanical coupling. However, recent studies have revealed that myokines, proteins secreted by skeletal muscle cells, play a crucial role in the regulation of bone metabolism. Myokines are widely involved in bone metabolism, influencing bone resorption and formation by interacting with factors related to bone cell secretion or influencing bone metabolic pathways. Here, we review the research progress on the myokine regulation of bone metabolism, discuss the mechanism of myokine regulation of bone metabolism, explore the pathophysiological relationship between sarcopenia and osteoporosis, and provide future perspectives on myokine research, with the aim of identify potential specific diagnostic markers and therapeutic entry points.
基金：
Yunnan Provincial Key Laboratory of Digital Orthopedics [202005AG070004]; Yunnan Orthopaedic and Sports Rehabilitation Clinical Medical Research Center [202102AA310068]; Yunnan Spinal Cord Disease Clinical Medical Center [ZX2022000101]; Yunnan Provincial Department of Science and Technology, Applied Basic Surface Project [202201AT070278]; First People's Hospital of Yunnan Province, High-level Talent Introduction Program [2022-KHRCBZ-B06]; First People's Hospital of Yunnan Province, Doctoral Research Fund [KHBS-2022-20]; Yunnan Provincial Department of Science and Technology, Kunming Medical Joint Special -Project [202201AC070436]
第一作者机构：[1]Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, Dept Orthoped Surg,Key Lab Digital Orthopaed Yunna, Kunming, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, Dept Orthoped Surg,Key Lab Digital Orthopaed Yunna, Kunming, Yunnan, Peoples R China[2]First Peoples Hosp Yunnan Prov, Kunming, Peoples R China
推荐引用方式(GB/T 7714)：
Shao Minghong,Wang Qiyang,Lv Qiunan,et al.Advances in the research on myokine-driven regulation of bone metabolism[J].HELIYON.2024,10(1):doi:10.1016/j.heliyon.2023.e22547.
APA：
Shao, Minghong,Wang, Qiyang,Lv, Qiunan,Zhang, Yuqiong,Gao, Guoxi&Lu, Sheng.(2024).Advances in the research on myokine-driven regulation of bone metabolism.HELIYON,10,(1)
MLA：
Shao, Minghong,et al."Advances in the research on myokine-driven regulation of bone metabolism".HELIYON 10..1(2024)
