机构：[1]Department of Gynecology, The First People’s Hospital of Yunnan Province, Kunming, China外科片妇科云南省第一人民医院[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China云南省第一人民医院[3]Department of Gynecology, The People’s Hospital of Hezhou, Hezhou, China
ObjectiveThis study aimed to investigate the impact of serum androgen levels on metabolic profiles in patients with polycystic ovary syndrome (PCOS).MethodsWe included 216 patients with PCOS and 216 healthy individuals selected as the control group. According to the measured serum androgen levels, patients with PCOS were divided into the hyperandrogenism group and non-hyperandrogenism group. Clinical metabolic indicators were assessed and compared between the two groups. Additionally, we assessed the correlation between androgen levels and clinical metabolic indicators.ResultsThe body mass index, waist-to-hip ratio, mF-G score, and acne score, as well as T, LH, LSH/FSH, FPG, Cr, UA, TG, TC, and LDL-C levels were significantly higher in the PCOS group than in the control group. The incidence of hyperandrogenism and clinical hyperandrogenism in the PCOS group was significantly higher than that in the control group. Regarding clinical hyperandrogenism, hirsutism, acne, and acanthosis nigricans were significantly more common in the PCOS group than in the control group. Serum androgen levels were significantly correlated with the mF-G score, acne score, FSH, glucose concentration at 30 min, glucose concentration at 60 min, glucose concentration at 120 min, FINS, N120, HOMA-IR, HbA1c, AUCG, UA, TG, and hHDL-Clevels.ConclusionElevated serum androgen levels are commonly observed in patients with PCOS and are associated with multiple metabolic abnormalities. Therefore, it is recommended to regularly monitor glucose and lipid metabolism-related indicators in patients with PCOS who have elevated androgen levels.
基金：
Yunnan Basic Research Program [2018FE117]; Yunnan Provincial Center for Obstetrics and Gynecology Research [2022YJZX-FC08, 2023YJZX-FC05]; Key Laboratory of Birth Defects and Genetic Diseases Research in Yunnan Province [2022ZDFKT002]
第一作者机构：[1]Department of Gynecology, The First People’s Hospital of Yunnan Province, Kunming, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gynecology, The First People’s Hospital of Yunnan Province, Kunming, China[2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China[*1]Gynecology Department, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming, 650032 Yunnan, China
推荐引用方式(GB/T 7714)：
Zhao Ting,Tao Xinghua,Xiao Xiao,et al.The impact of androgen levels on serum metabolic profiles in patients with polycystic ovary syndrome[J].GYNECOLOGICAL ENDOCRINOLOGY.2024,40(1):doi:10.1080/09513590.2024.2352136.
APA：
Zhao, Ting,Tao, Xinghua,Xiao, Xiao,Li, Lingchuan,Wu, Xiaomei&Yuan, Tao.(2024).The impact of androgen levels on serum metabolic profiles in patients with polycystic ovary syndrome.GYNECOLOGICAL ENDOCRINOLOGY,40,(1)
MLA：
Zhao, Ting,et al."The impact of androgen levels on serum metabolic profiles in patients with polycystic ovary syndrome".GYNECOLOGICAL ENDOCRINOLOGY 40..1(2024)
