Background and Objective: Re-vascularization is an effective treatment for moyamoya disease (MMD) patients, including direct re-vascularization, indirect re-vascularization and combined re-vascularization, in which combined re-vascularization is particularly widely used. At present, there are few reports on the analysis of epilepsy after combined re-vascularization surgery. To analysis the risk factors of epilepsy in adult MMD patients after combined re-vascularization. Material and Methods: Patients with MMD who underwent combined re-vascularization in the Department of Neurosurgery of the First People's Hospital of Yunnan Province from January 2015 to June 2020 were included. Their pre-operative and post-operative complication-related indicators were collected. Finally, logistic regression was used to analyze the clinical risk factors of epilepsy in MMD patients after operation. Results: The incidence of epilepsy after combined re-vascularization was 15.5%. Univariate analysis showed that pre-operative ischemic or hemorrhagic stroke, pre-operative epilepsy, pre-operative history of diabetes, the location of the bypass recipient artery (frontal or temporal lobe), post-operative new cerebral infarction, hyper-perfusion syndrome, and post-operative intra-cranial hemorrhage were the clinical risk factors of epilepsy in MMD patients (all P < 0.05). Multi-variate logistic regression analysis showed that pre-operative epilepsy, the location of the bypass recipient artery, new cerebral infarction, hyper-perfusion syndrome, and post-operative intra-cranial hemorrhage (all P < 0.05) were independent risk factors for post-operative epilepsy in MMD patients. Conclusions: Pre-operative epilepsy, the location of the bypass recipient artery, new cerebral infarction, hyper-perfusion syndrome, and intra-cranial hemorrhage may have a causal relationship with epilepsy in adult MMD patients. It is suggested that some risk factors could be intervened to reduce the incidence of post-operative epilepsy in MMD patients.
基金:
Joint Project of Yunnan Science and Technology Department and Kunming Medical University [2019FE001(-160)]; Yunnan Fundamental Research Projects [202201AT070014]; Open Project of the Clinical Medical Center of the First People's Hospital of Yunnan Province [2021LCZXXF-SJ04]; Yunnan health training project of high-level talents [H-2017030]
第一作者机构:[1]Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, 157 Jinbi Rd, Kunming, Yunnan, Peoples R China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Liu Erheng,Jin Lide,Tao Weihua,et al.Analysis of Risk Factors for Epilepsy after Combined Re-Vascularization in Adult Patients with Moyamoya Disease[J].NEUROLOGY INDIA.2023,71(3):471-475.doi:10.4103/0028-3886.378661.
APA:
Liu, Erheng,Jin, Lide,Tao, Weihua,Tan, Xueyi,Liu, Chengyuan...&Yang, Shuaifeng.(2023).Analysis of Risk Factors for Epilepsy after Combined Re-Vascularization in Adult Patients with Moyamoya Disease.NEUROLOGY INDIA,71,(3)
MLA:
Liu, Erheng,et al."Analysis of Risk Factors for Epilepsy after Combined Re-Vascularization in Adult Patients with Moyamoya Disease".NEUROLOGY INDIA 71..3(2023):471-475