Infertility affects approximately one-sixth of couples globally, with the incidence of male infertility steadily increasing. However, our understanding of the impact of viral infections on fertility remains limited. This review consolidates findings from previous studies, outlining 40 viruses identified in human semen and summarizing their key characteristics, modes of transmission, and their effects on both the reproductive and endocrine systems. Furthermore, it elucidates potential pathogenic mechanisms and treatment prospects of viruses strongly associated with male infertility. This synthesis will enhance our comprehension of how viral infections influence male reproductive health, offering valuable insights for future research as well as the diagnosis and treatment of infectious infertility.Graphical AbstractAbbreviated summary: Semen viral infections can damage the male reproductive system, further affecting semen quality and causing infertility, as well as sexually transmitted infections to partners and vertical transmission resulting in poor pregnancy outcomes.
基金：
Yunnan
Major Scientifc and Technological Projects (202302AA310044), the National
Key Research and Development Program of China (2021YFA0805703), the Kunming University of Science and Technology & the First People’s Hospital of Yunnan Province Joint Special Project on Medical Research (KUST-KH2022003Z),
the Yunnan Provincial Young and Middle-aged Academic and Technical Leaders
Reserve Talents Program (202305AC160022), the Open project of Clinical Medical Research Center of the First People’s Hospital of Yunnan Province (2022YJZXFC16), the National Natural Science Foundation of China (32270981, 82160294,
82360304), the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University (202401AY070001-
301, 202301AY070001-003, 202101AY070001-260, 202301AY070001-298), Open
project of Yunnan Provincial Reproductive and Obstetrics and Gynecology
Clinical Medicine Center (2022LCZXKF-SZ04), Key Projects of Yunnan Province Science and Technology Department (202302AA310044).
第一作者机构：[1]First Peoples Hosp Yunnan Prov, Dept Reprod Gynecol, NHC Key Lab Hlth Birth & Birth Defect Prevent West, Kunming, Yunnan, Peoples R China[4]Kunming Univ Sci & Technol, Affiliated Hosp, Kunming, Yunnan, Peoples R China[5]Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]First Peoples Hosp Yunnan Prov, Dept Reprod Med, NHC Key Lab Hlth Birth & Birth Defect Prevent West, Kunming, Yunnan, Peoples R China[3]Kunming Univ Sci & Technol, KUST YPFPH Reprod Med Joint Res Ctr, Med Sch, Kunming, Yunnan, Peoples R China[4]Kunming Univ Sci & Technol, Affiliated Hosp, Kunming, Yunnan, Peoples R China
推荐引用方式(GB/T 7714)：
Guo Yan,Dong Yunhua,Zheng Runzi,et al.Correlation between viral infections in male semen and infertility: a literature review[J].VIROLOGY JOURNAL.2024,21(1):doi:10.1186/s12985-024-02431-w.
APA：
Guo, Yan,Dong, Yunhua,Zheng, Runzi,Yan, Jiacong,Li, Weiyuan...&Xiang, Lifeng.(2024).Correlation between viral infections in male semen and infertility: a literature review.VIROLOGY JOURNAL,21,(1)
MLA：
Guo, Yan,et al."Correlation between viral infections in male semen and infertility: a literature review".VIROLOGY JOURNAL 21..1(2024)
