Sorting nexin 10 (SNX10) expression induces intestinal barrier dysfunction and inflammatory responses; in contrast, its inhibition promotes intestinal mucosal healing through sterol regulatory element-binding protein 2 (SREBP2)-mediated cholesterol synthesis. However, its regulatory mechanism for the pathogenesis of inflammatory bowel disease (IBD) remains unclear. In this study, we examined SNX10 and SREBP2 expression in ulcerative colitis (UC) and Crohn's disease (CD). A total of 30 and 28 patients with UC and CD, respectively, were recruited. The expression of SNX10 and SREBP2 in the colonic mucosa was measured by immunohistochemistry (IHC). We discovered that patients with CD had significantly higher expression levels of SNX10 and SREBP2 than patients with UC and healthy controls. In addition, the expression of SREBP2 in patients with UC was significantly higher than that in healthy controls. In our study, we indicated that SNX10 and SREBP2 may serve as biomarkers for identifying patients with UC and CD, thereby providing a clinical therapeutic strategy for the treatment of IBD by inhibiting SNX10.
基金：
National Natural Science Foundation of China [81860105]; Special Joint Program of Yunnan Province [202301AY070001-058, 202401AY070001-040]; Yunnan Youth Top Talent Project of High-Level Talents [YNWR-QNBJ-2020-236]; Yunnan Health Training Project of High-Level Talents Medical Reserve Talent Project [H-2019036]; Kunming University of Science and Technology; First People's Hospital of Yunnan Province Joint Special Project on Medical Research [KUST- KH2022013Y]; Yunnan Key Laboratory of Innovative Application of Traditional Chinese Medicine [202105AG070032]
第一作者机构：[1]Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Yunnan Digest Dis Clin Med Ctr, Dept Gastroenterol,Affiliated Hosp, 157 Jingbi Rd, Kunming 650032, Yunnan, Peoples R China
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推荐引用方式(GB/T 7714)：
Xie Bicheng,Zhang Anxing,Li Canmei,et al.Differential analysis of sorting nexin 10 and sterol regulatory element-binding protein 2 expression in inflammatory bowel disease[J].IMMUNOLOGIC RESEARCH.2024,72(6):1417-1423.doi:10.1007/s12026-024-09539-9.
APA：
Xie, Bicheng,Zhang, Anxing,Li, Canmei,Liu, Yu,Deng, Yao...&Lan, Danfeng.(2024).Differential analysis of sorting nexin 10 and sterol regulatory element-binding protein 2 expression in inflammatory bowel disease.IMMUNOLOGIC RESEARCH,72,(6)
MLA：
Xie, Bicheng,et al."Differential analysis of sorting nexin 10 and sterol regulatory element-binding protein 2 expression in inflammatory bowel disease".IMMUNOLOGIC RESEARCH 72..6(2024):1417-1423
