机构：[1]Departments of Medical Neurosurgery, The First Affiliated Hospital of Kunming Medical University,Kunming, Yunnan 650032昆明医科大学附属第一医院[2]Departments of Medical Imaging, The First Affiliated Hospital of Kunming Medical University,Kunming, Yunnan 650032昆明医科大学附属第一医院[3]School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products[4]Biomedical Engineering Center, Kunming Medical University, Kunming, Yunnan 650500, P.R. China
Epigallocatechin-3-gallate (EGCG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of EGCG in a high-fat diet and streptozotocin-induced type 2 diabetes mellitus (T2DM) mouse model. The results demonstrated that EGCG can decrease blood glucose levels and increase insulin resistance in T2DM mice. In addition, EGCG can regulate serum lipid levels, including those of total cholesterol, triglyceride and low-density lipoprotein receptor (LDL-r), and reduce lipid deposition in vascular endothelial cells in a dose-dependent manner. In addition, the gene and protein expression of related scavenger receptors, including cluster of differentiation 36, sterol regulatory element binding protein 2 (SREBP), SREBP cleavage-activating protein and LDL-r, were downregulated in a dose-dependent manner. The present study noted that EGCG possesses potential as a natural product for preventing and treating metabolic hyperlipidemia syndrome, probably by reducing the blood lipid levels, alleviating vascular endothelial cell damage, maintaining normal lipid metabolism in blood vessels and ameliorating glycolipid disorders.
基金：
Yunnan Applied Basic Research Projects-Joint Special Project [2018FE001(-210)]; Yunnan Provincial Education Department Project [2017ZDX157, 2020J0151]
第一作者机构：[1]Departments of Medical Neurosurgery, The First Affiliated Hospital of Kunming Medical University,Kunming, Yunnan 650032
通讯作者：
通讯机构：[4]Biomedical Engineering Center, Kunming Medical University, Kunming, Yunnan 650500, P.R. China[*1]Biomedical Engineering Center,Kunming Medical University, 1168 Chunrongxi Road, Kunming,Yunnan 650500, P.R. China
推荐引用方式(GB/T 7714)：
Ren Zhongkun,Yang Zhiyong,Lu Yi,et al.Anti-glycolipid disorder effect of epigallocatechin-3-gallate on high-fat diet and STZ-induced T2DM in mice[J].MOLECULAR MEDICINE REPORTS.2020,21(6):2475-2483.doi:10.3892/mmr.2020.11041.
APA：
Ren, Zhongkun,Yang, Zhiyong,Lu, Yi,Zhang, Rongping&Yang, Hui.(2020).Anti-glycolipid disorder effect of epigallocatechin-3-gallate on high-fat diet and STZ-induced T2DM in mice.MOLECULAR MEDICINE REPORTS,21,(6)
MLA：
Ren, Zhongkun,et al."Anti-glycolipid disorder effect of epigallocatechin-3-gallate on high-fat diet and STZ-induced T2DM in mice".MOLECULAR MEDICINE REPORTS 21..6(2020):2475-2483
