Two previously undescribed chroman-type polyketides, trichrontides A (1) and B (2), along with four known homologous compounds, were isolated from the endophytic fungus Trichoderma sp. YUD24002, which was associated with Aconitum forrestii Stapf. Their structures were confirmed using NMR and HR-ESI-MS techniques. Furthermore, the absolute configurations of the two new compounds were elucidated through TDDFT ECD calculations and Mosher's methods. Notably, compound 1 exhibited significant antifungal activity against Alternaria panax, with a minimum inhibitory concentration (MIC) of 16 mu g/mL, while compound 2 demonstrated evident antifungal activity against Epicoccum nigrum, with a MIC of 32 mu g/mL.
基金：
Science and Technology Project of Yunnan Provincial Department of Science and Technology; Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University [202401AY070001-129]; Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform [2022YKZY001]; Kunming University of Science and Technology medical joint project; Open project of Yunnan Clinical Medical Center [2023YJZX-YX01]; [202201AT070225]
第一作者机构：[1]Yunnan Univ, Funct Mol Anal & Biotransformat Key Lab Univ Yunna, Yunnan Characterist Plant Extract Lab, Sch Chem Sci & Technol,Key Lab Med Chem Nat Resour, Kunming, Peoples R China
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推荐引用方式(GB/T 7714)：
Zi Zhi-Feng,Xie Fei,Wang Wen-Jing,et al.Two Chroman Type Polyketides From Trichoderma sp. YUD24002 Associated With Aconitum[J].CHEMISTRY & BIODIVERSITY.2024,doi:10.1002/cbdv.202402744.
APA：
Zi, Zhi-Feng,Xie, Fei,Wang, Wen-Jing,Xia, Dan-Dan,Wan, Dai-Yu...&Ma, Ling.(2024).Two Chroman Type Polyketides From Trichoderma sp. YUD24002 Associated With Aconitum.CHEMISTRY & BIODIVERSITY,,
MLA：
Zi, Zhi-Feng,et al."Two Chroman Type Polyketides From Trichoderma sp. YUD24002 Associated With Aconitum".CHEMISTRY & BIODIVERSITY .(2024)
