机构：[1]Hainan Med Univ, Hainan Acad Med Sci, Hainan Pharmaceut Res & Dev Sci Pk, Haikou, Peoples R China[2]Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, Dept Pharm, Kunming, Peoples R China医技片药学部云南省第一人民医院[3]Fujian Med Univ, Sch Basic Med Sci, Fuzhou, Peoples R China
One new monomeric citrinin analog (1) and 42 known compounds (2-43) were isolated from Penicillium citrinum W22. The structure of 1 was determined by detailed analysis of the 1D and 2D nuclear magnetic resonance (NMR), HRESIMS, and time-dependent density functional theory (TD-DFT)-based electronic circular dichroism (ECD) calculation. Penicitrinol A (2) and methyl 2-(2-acetyl-3,5-dihydroxy-4,6-dimethylphenyl) acetate (11) significantly inhibited renin-angiotensin system-selective lethal 3 (RSL3)-induced ferroptosis with half maximal effective concentration (EC50) values of 1.6 and 34.0 mu M, respectively.
基金：
Open Projects for Construction Unit of Clinical Pharmacy Center of Yunnan Province [2023YJZX-YX15]; Xiamen Southern Oceanographic Center [22GYY007HJ07]
第一作者机构：[1]Hainan Med Univ, Hainan Acad Med Sci, Hainan Pharmaceut Res & Dev Sci Pk, Haikou, Peoples R China
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通讯作者：
推荐引用方式(GB/T 7714)：
Zou Zheng-Biao,Ma Yan-Lin,Li Yan,et al.Chemical Constituents of the Deep-Sea-Derived Penicillium citrinum W22 and Their Ferroptosis Inhibitory Activity[J].CHEMISTRY & BIODIVERSITY.2025,doi:10.1002/cbdv.202403319.
APA：
Zou, Zheng-Biao,Ma, Yan-Lin,Li, Yan,Nie, Shan-Shan,Li, You...&Yang, Xian-Wen.(2025).Chemical Constituents of the Deep-Sea-Derived Penicillium citrinum W22 and Their Ferroptosis Inhibitory Activity.CHEMISTRY & BIODIVERSITY,,
MLA：
Zou, Zheng-Biao,et al."Chemical Constituents of the Deep-Sea-Derived Penicillium citrinum W22 and Their Ferroptosis Inhibitory Activity".CHEMISTRY & BIODIVERSITY .(2025)
