Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis
机构：[1]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan Province, China.[2]Department of Pharmacy, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, China.[3]College of Pharmacy, Dali University, Dali, Yunnan Province, China.[4]National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, Yunnan Province, China.
This study aim to assess the clinical efficacy and safety of generic cefoperazone/sulbactam compared to the branded cefoperazone/sulbactam (Sulperazon) in treating bacterial infections through a meta-analysis. Searches were conducted across PubMed, Embase, Cochrane Library, CNKI, WanFang, VIP databases, and Clinical Trials database, resulting in the inclusion of 11 studies comprising 7 randomized controlled trials (RCTs) and 4 retrospective cohort studies (RCSs). Meta-analysis of the RCTs indicated no statistical differences in clinical success rates, clinical cure rates, microbiological eradication rates, and incidence of adverse reactions between the generic cefoperazone/sulbactam and the branded version. Findings from the RCSs aligned with those from the RCTs, demonstrating that generic versions of cefoperazone/sulbactam are equivalent in efficacy and safety to their branded counterparts in treating bacterial infections.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|4 区医学
小类|4 区传染病学4 区肿瘤学4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区传染病学4 区肿瘤学4 区药学
第一作者：
第一作者机构：[1]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan Province, China.
通讯作者：
通讯机构：[1]Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan Province, China.[3]College of Pharmacy, Dali University, Dali, Yunnan Province, China.[4]National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, Yunnan Province, China.
推荐引用方式(GB/T 7714)：
Wu Rui,Wang Xuechang,Cui Pumei,et al.Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis[J].Journal Of Chemotherapy (Florence, Italy).2024,36(8):698-708.doi:10.1080/1120009X.2024.2343961.
APA：
Wu Rui,Wang Xuechang,Cui Pumei,Chen Wei,Yang Wanqi&Lai Yong.(2024).Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis.Journal Of Chemotherapy (Florence, Italy),36,(8)
MLA：
Wu Rui,et al."Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis".Journal Of Chemotherapy (Florence, Italy) 36..8(2024):698-708
