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Coxsackievirus-A10 induced RIPK3-driven necroptosis to promote the formation of inflammatory response and enhance virus production via being recognized by TLR3

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机构： [1]Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Yunnan Province, China [2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China. [3]National & Local Engineering Center for Infectious Biological Products, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China.

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关键词： Hand foot and mouth disease (HFMD) Coxsackievirus-A10 (CV-A10) RIPK3-dependent necroptosis Toll like receptor 3 (TLR3)

摘要：

Neuronal death and neuroinflammation has been considered as the main contributors to the progression and deterioration of HFMD caused by CV-A10. Necroptosis is a lytic and inflammatory form of cell death that plays a crucial role in viral pathogenicity. Herein, our study showed that CV-A10-infected SH-SY5Y cells induced necroptosis via activating RIPK3-depedent pathway, but not requiring RIPK1, and meanwhile triggered the release of inflammatory cytokines. Moreover, RIPK3-mediated necroptosis was also involved in virus production, which did not require RIPK1 either. Finally, it was further verified that TLR3 drove RIPK3-mediated cell death by sensing CV-A10 RNA and activating RIPK3. Collectively, our study demonstrated that initiation of necroptosis in SH-SY5Y cells induced by CV-A10 accelerated the formation of inflammatory response and promoted virus replication through triggering a TLR3-initiated RIPK3-dependent pathway of necroptosis, which advanced the current understanding of necroptosis for the neuropathogenesis of CV-A10 infection.Copyright © 2025 Elsevier Ltd. All rights reserved.

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出版当年[2025]版：

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最新[2025]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区免疫学

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出版当年[2024]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 IMMUNOLOGY

最新[2024]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 IMMUNOLOGY

影响因子： 3 最新[2024版] 3.4 最新五年平均 3 出版当年[2024版] 3.4 出版当年五年平均 3.2 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Yunnan Province, China [2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.

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通讯作者：

通讯机构： [1]Department of Pulmonary and Critical Care Medicine, The First People's Hospital of Yunnan Province, China [2]The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.

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