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Comprehensive profiling and characterization of cellular microRNAs in response to coxsackievirus A10 infection in bronchial epithelial cells

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机构: [1]First Peoples Hosp Yunnan Prov, Dept Pulm & Crit Care Med, Kunming, Yunnan, Peoples R China [2]Kunming Univ Sci & Technol, Affiliated Hosp, Kunming, Yunnan, Peoples R China [3]First Peoples Hosp Yunnan Prov, Dept Anesthesiol, Kunming, Yunnan, Peoples R China [4]Chinese Acad Med Sci & Peking Union Med Coll, Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, Inst Med Biol, Kunming, Yunnan, Peoples R China
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关键词: Hand foot and mouth disease (HFMD) Coxsackievirus A10 (CV-A10) MicroRNAs (miRNAs) High-throughput sequencing Bioinformatics analysis

摘要:
Coxsackievirus A10 (CV-A10), the causative agent of hand, foot, and mouth disease (HFMD), caused a series of outbreaks in recent years and often leads to neurological impairment, but a clear understanding of the disease pathogenesis and host response remains elusive. Cellular microRNAs (miRNAs), a large family of non-coding RNA molecules, have been reported to be key regulators in viral pathogenesis and virus-host interactions. However, the role of host cellular miRNAs defensing against CV-A10 infection is still obscure. To address this issue, we systematically analyzed miRNA expression profiles in CV-A10-infected 16HBE cells by high-throughput sequencing methods in this study. It allowed us to successfully identify 312 and 278 miRNAs with differential expression at 12 h and 24 h post-CV-A10 infection, respectively. Among these, 4 miRNAs and their target genes were analyzed by RT-qPCR, which confirmed the sequencing data. Gene target prediction and enrichment analysis revealed that the predicted targets of these miRNAs were significantly enriched in numerous cellular processes, especially in regulation of basic physical process, host immune response and neurological impairment. And the integrated network was built to further indicate the regulatory roles of miRNAs in host-CV-A10 interactions. Consequently, our findings could provide a beneficial basis for further studies on the regulatory roles of miRNAs relevant to the host immune responses and neuropathogenesis caused by CV-A10 infection.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 病毒学
最新[2023]版:
大类 | 3 区 医学
小类 | 2 区 病毒学
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出版当年[2021]版:
Q2 VIROLOGY
最新[2023]版:
Q2 VIROLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]First Peoples Hosp Yunnan Prov, Dept Pulm & Crit Care Med, Kunming, Yunnan, Peoples R China [2]Kunming Univ Sci & Technol, Affiliated Hosp, Kunming, Yunnan, Peoples R China
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通讯机构: [1]First Peoples Hosp Yunnan Prov, Dept Pulm & Crit Care Med, Kunming, Yunnan, Peoples R China [2]Kunming Univ Sci & Technol, Affiliated Hosp, Kunming, Yunnan, Peoples R China
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