机构：[1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China 四川大学华西医院[2]State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China 四川大学华西医院[3]Department of Neurosurgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China [4]Department of Neurosurgery, The Fifth People’s Hospital of Ningxia, Shizuishan, China [5]Department of Pediatric Neurosurgery, West China Second University Hospital, Sichuan University, Chengdu, China [6]Department of Neurosurgery, Afliated Hospital of Southwest Medical University, Sichuan Province, Luzhou City, China [7]Department of Neurosurgery,The First People’S Hospital of Yunnan Province,the Afliated Hospital of Kunming University of Science and Technology) Kunming,Yunan,China外科片神经外科云南省第一人民医院[8]Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China
Hydrocephalus is one of the most common neurological diseases, characterized by abnormal excessive accumulation of cerebrospinal fluid (CSF) in the ventricular system. Its pathophysiological mechanism is believed to be related to the imbalance of CSF circulation and homeostasis. As the main source of CSF secretion, the choroid plexus is closely related to hydrocephalus. The choroid plexus is a specialized vascularized tissue located within the cerebral ventricles. It has multiple physiological functions including regulating CSF, immune response, endocrine metabolism, etc. Strategies that reduce choroid plexus CSF secretion have been shown to be effective in the treatment of hydrocephalus. However, the role of other physiological functions of the choroid plexus in hydrocephalus is still unclear. Recent studies on the choroid plexus and the blood-CSF barrier have deepened our understanding of the structure and function of the choroid plexus. The idea of targeting the choroid plexus to treat hydrocephalus has spawned many branches: choroid plexus epithelial cells, choroid plexus immune cells, choroid plexus peptides, and choroid plexus cilia, etc. This review introduces the basic structure and function of the choroid plexus, summarizes their changes in hydrocephalus, and analyzes the possibility of the choroid plexus as a therapeutic target for hydrocephalus.
基金：
National Natural Science Foundation of China (Grant: 82473334), the Major Scientifc and Technological Achievements Transformation Project of Ningxia Hui Autonomous Region (Grant: 2022CJE09013), the NHC Key Laboratory of Nuclear Technology Medical Transformation (Miyang Central hospital) (Grants: 2023HYX001 and 2023HYX014), and Mianyang Key Laboratory of Anesthesia and Neuroregulation (Grant: MZSJ202304).
第一作者机构：[1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China [2]State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China [3]Department of Neurosurgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China [4]Department of Neurosurgery, The Fifth People’s Hospital of Ningxia, Shizuishan, China [8]Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China
推荐引用方式(GB/T 7714)：
Deng Ziang,Wang Haoxiang,Zhong Kunhong,et al.The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target[J].MOLECULAR NEUROBIOLOGY.2025,doi:10.1007/s12035-025-04823-7.
APA：
Deng, Ziang,Wang, Haoxiang,Zhong, Kunhong,Li, Yuanyou,Deng, Huajiang...&Zhou, Liangxue.(2025).The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target.MOLECULAR NEUROBIOLOGY,,
MLA：
Deng, Ziang,et al."The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target".MOLECULAR NEUROBIOLOGY .(2025)
