机构：[1]Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.[2]Division of Liver Surgery, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[3]Hepatobiliary and Pancreatic Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.外科片肝胆外科云南省第一人民医院
miR-145-5p regulates drug sensitivity in various cancer types and is also expressed at significantly low levels in pancreatic cancer (PC), but its role in PC resistance to gemcitabine is not yet clear. This study revealed low expression of miR-145-5p in the PC gemcitabine-resistant cell lines SW1990/GEM and PANC-1/GEM. The overexpression of miR-145-5p inhibited the proliferation and migration of PC drug-resistant cells. Mechanistically, miR-145-5p overexpression increased the sensitivity of PC drug-resistant cells to gemcitabine through the inhibition of CDCA3, thereby inhibiting the proliferation and migration of PC drug-resistant cells. Our study indicated that the upregulation of miR-145-5p expression might be an effective target for improving the treatment efficacy of PC.
基金：
Kunming Medical Joint Special Project-Surface Project (202201AY070001-105 and 202201AY070001-107), Yunnan Special Basic Research ProjectsYouth Program (202201AU070198), Doctor of Scientific Research
Project of the Second Affiliated Hospital of Kunming Medical
University (2023BS08), Scientific Research Fund Project of Yunnan
Provincial Department of Education (2022J0260).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2025]版：
大类|4 区生物学
小类|4 区生化与分子生物学4 区生物物理4 区生理学
第一作者：
第一作者机构：[1]Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ge Jiayun,Zhang Zhihong,Shao Guohui,et al.miR-145-5p modulates CDCA3 to overcome gemcitabine resistance in pancreatic cancer[J].General Physiology And Biophysics.2025,44(2):175-183.doi:10.4149/gpb_2024047.
APA：
Ge Jiayun,Zhang Zhihong,Shao Guohui,Wei Dong,Tang Bo...&Wang Xin.(2025).miR-145-5p modulates CDCA3 to overcome gemcitabine resistance in pancreatic cancer.General Physiology And Biophysics,44,(2)
MLA：
Ge Jiayun,et al."miR-145-5p modulates CDCA3 to overcome gemcitabine resistance in pancreatic cancer".General Physiology And Biophysics 44..2(2025):175-183
