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Association of seizure control during pregnancy with adverse offspring outcomes in women with epilepsy

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收录情况： ◇ SCIE

作者：
Fu, Yutong[1] * ; Shi, Fanfan[2] * ; Sha, Leihao[1] ; Lin, Weihong[3] ; Ma, Ying[4] ; Yan, Hua[5] ; Wang, Pei[6] ; Fang, Jiajia[7] ; Huang, Qun[8] ; Chen, Fang[9] ; Li, Xiaoyi[10] ; Li, Yun[11] ; Liu, Changqing[12] ; Kong, Qingxia[13] ; Huang, Hua[14] ; Zhang, Qi[15] ; Mei, Rong[16] ; Wu, Yuan[17] ; He, Shixu[18] ; Han, Yanbing[19] ; Zhang, Hua[20] ; Xiao, Bo[21] ; Wang, Kuiyun[22] ; Peng, Zhanghui[23] ; Zhu, Xi[24,25] ; Wang, Jian[26] ; Wu, Xunyi[27] ; Zhu, Yanmei[28] ; Wu, Ting[29] ; He, Xuelian[30] ; Guo, Haizhi[31] ; Yu, Ming[32] ; Zhong, Min[33] ; Zhang, Qing[34] ; Hu, Xiangshu[35] ; Su, Yan[36] ; Zou, Mei[37] ; Zhou, Jian[38] ; Liu, Yaqing[39] ; Pu, Bozhong[40,41] ; Guo, Chonglun[42] ; Feng, Qin[43] ; Gao, Jing[44] ; Lin, Wanhui[45] ; Tomson, Torbjoern[46] ; Chen, Lei[1] ;
机构： [1]Sichuan Univ, Dept Neurol, West China Hosp, Chengdu, Sichuan, Peoples R China [2]Sichuan Univ, West China Hosp, Ctr Biostat Design Measurement & Evaluat CBDME, Dept Clin Res & Management, Chengdu, Sichuan, Peoples R China [3]Jilin Univ, Bethune Hosp 1, Changchun, Jilin, Peoples R China [4]North Sichuan Med Coll, Affiliated Hosp, Dept Neurol, Nanchong, Sichuan, Peoples R China [5]Jianyang Peoples Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China [6]Xianyang First Peoples Hosp, Dept Neurol, Xianyang, Shanxi, Peoples R China [7]Zhejiang Univ, Sch Med, Dept Neurol, Affiliated Hosp 4, Yiwu, Zhejiang, Peoples R China [8]WenJiang Maternal & Child Hlth Hosp, Chengdu, Sichuan, Peoples R China [9]Sichuan Prov Peoples Hosp, Jinniu Hosp, Dept Neurol, Chengdu, Peoples R China [10]Guizhou Prov Peoples Hosp, Dept Neurol, Guiyang, Guizhou, Peoples R China [11]Dali Univ, Affiliated Hosp 1, Dept Neurol, Dali, Yunnan, Peoples R China [12]Chongqing Sanbo Jiangling Hosp, Dept Neurol, Chongqing, Peoples R China [13]Jining Med Univ, Affiliated Hosp, Dept Neurol, Jining, Shandong, Peoples R China [14]Dazhou Cent Hosp, Dept Neurol, Dazhou, Sichuan, Peoples R China [15]Chengdu Off Peoples Govt Tibetan Autonomous Reg, Dept Neurol, Chengdu, Sichuan, Peoples R China [16]First Peoples Hosp Yunnan Prov, Dept Neurol, Kunming, Yunnan, Peoples R China [17]Guangxi Med Univ, Affiliated Hosp 1, Dept Neurol, Nanning, Guangxi, Peoples R China [18]Chengdu Mental Hlth Ctr, Chengdu, Peoples R China [19]Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming, Yunnan, Peoples R China [20]Xi An Jiao Tong Univ, Affiliat Hosp 1, Dept Neurol, Xian, Peoples R China [21]Shenzhen Second Peoples Hosp, Shenzhen, Peoples R China [22]Jintang First Peoples Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China [23]Guangan Peoples Hosp, Dept Neurol, Guangan, Sichuan, Peoples R China [24]Third Peoples Hosp Chengdu, Dept Neurol, Chengdu, Peoples R China [25]Dujiangyan Med Ctr, Chengdu, Peoples R China [26]Second Peoples Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China [27]Fudan Univ, Dept Neurol, Huashan Hosp, Shanghai, Peoples R China [28]Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin, Heilongjiang, Peoples R China [29]Jiangsu Prov Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China [30]Pengxi Cty Peoples Hosp, Dept Neurol, Suining, Sichuan, Peoples R China [31]Ziyang First Peoples Hosp, Dept Neurol, Ziyang, Sichuan, Peoples R China [32]Suining Cent Hosp, Dept Neurol, Suining, Sichuan, Peoples R China [33]Santai Cty Peoples Hosp, Dept Neurol, Mianyang, Sichuan, Peoples R China [34]Ningxia Med Univ, Gen Hosp, Dept Neurol, Yinchuan, Ningxia, Peoples R China [35]Guangdong Second Prov Gen Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China [36]First Peoples Hosp, Dept Neurol, Baiyin, Gansu, Peoples R China [37]First Peoples Hosp Liangshan Yi Autonomous Prefect, Dept Neurol, Xichang, Sichuan, Peoples R China [38]Capital Med Univ, Dept Neurosurg, Sanbo Brain Hosp, Beijing, Peoples R China [39]Lanzhou Univ, Dept Neurol, Hosp 2, Lanzhou, Gansu, Peoples R China [40]Chengdu Univ, Clin Med Coll, Dept Neurol, Chengdu, Sichuan, Peoples R China [41]Chengdu Univ, Affiliated Hosp, Chengdu, Sichuan, Peoples R China [42]Suichuan Cty Peoples Hosp, Suichuan, Jiangxi, Peoples R China [43]Deyang Peoples Hosp, Dept Neurol, Deyang, Sichuan, Peoples R China [44]Kunming Sanbo Brain Hosp, Dept Neurol, Kunming, Yunnan, Peoples R China [45]Fujian Med Univ, Union Hosp, Dept Neurol, Fuzhou, Fujian, Peoples R China [46]Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
出处：
DOI： 10.1136/jnnp-2024-335751
ISSN：

关键词： EPILEPSY EPIDEMIOLOGY SEIZURES

摘要：
Background Information on fetal risks with maternal seizures during pregnancy is scarce. This study investigates seizure control during pregnancy and fetal risks associated with maternal seizures in different stages of pregnancy among pregnant women with epilepsy (PWWE).Methods The nested case-control study enrolled PWWE between 2009 and 2023 in China. Information was obtained on maternal seizures, antiseizure medication (ASM), folic acid supplementation and pregnancy outcomes. The primary outcome was composite including major congenital malformations (MCMs), neurodevelopmental delay, low birth weight (LBW) and fetal death. Univariate and multivariate logistic regression analyses were conducted to adjust for ASM effects and other confounders.Results Among 1110 pregnancies from 934 PWWE included, 56.6% experienced seizures. Seizure deterioration during pregnancy compared with prepregnancy was observed in 25.9% of pregnancies, while 20.9% experienced worsening seizures from the first to second or third trimesters. Seizures (adjusted OR (aOR) 1.472, 95% CI 1.024 to 2.137), particularly status epilepticus (aOR 2.906, 95% CI 1.364 to 5.93), generalised tonic-clonic seizures (aOR 1.581, 95% CI 1.066 to 2.354) and seizure deterioration (aOR 1.829, 95% CI 1.233 to 2.69) were associated with composite adverse outcomes. Specifically, seizures occurring (aOR 2.324, 95% CI 1.320 to 4.084) or deteriorating (aOR 2.396, 95% CI 1.471 to 3.866) during second and third trimesters were associated with the risk of LBW. No significant association was found between seizures and MCMs.Conclusions While nearly half of PWWE remain seizure-free during pregnancy, those who do experience seizures face increased risks of adverse offspring outcomes. For PWWE, every effort should be made to optimise seizure control in order to minimise risks to both mother and child. Trial registration number: ChiCTR2100046318Conclusions While nearly half of PWWE remain seizure-free during pregnancy, those who do experience seizures face increased risks of adverse offspring outcomes. For PWWE, every effort should be made to optimise seizure control in order to minimise risks to both mother and child. Trial registration number: ChiCTR2100046318

基金：
Sichuan Science and Technology Program Grant/Award Number: 2024ZDZX0018.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 精神病学 1 区 外科
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY Q1 SURGERY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Sichuan Univ, Dept Neurol, West China Hosp, Chengdu, Sichuan, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Fu Yutong,Shi Fanfan,Sha Leihao,et al.Association of seizure control during pregnancy with adverse offspring outcomes in women with epilepsy[J].JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY.2025,doi:10.1136/jnnp-2024-335751.
APA：
Fu, Yutong,Shi, Fanfan,Sha, Leihao,Lin, Weihong,Ma, Ying...&Chen, Lei.(2025).Association of seizure control during pregnancy with adverse offspring outcomes in women with epilepsy.JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,,
MLA：
Fu, Yutong,et al."Association of seizure control during pregnancy with adverse offspring outcomes in women with epilepsy".JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY .(2025)

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