机构：[1]Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China昆明医科大学附属第一医院[2]Biomedicine Engineering Research Center, Kunming Medical University, 1168 Chun RongWest Road, Kunming, Yunnan 650500, PR China[3]Department of Neurology, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, PR China
Epilepsy is a common neurological disease characterized by recurrent seizures. About 70 million people were affected by epilepsy or epileptic seizures. Epilepsy is a complicated complex or symptomatic syndromes induced by structural, functional, and genetic causes. Meanwhile, several comorbidities are accompanied by epileptic seizures. Cognitive dysfunction is a long-standing complication associated with epileptic seizures, which severely impairs quality of life. Although the definitive pathogenic mechanisms underlying epilepsy-related cognitive dysfunction remain unclear, accumulating evidence indicates that multiple risk factors are probably involved in the development and progression of cognitive dysfunction in patients with epilepsy. These factors include the underlying etiology, recurrent seizures or status epilepticus, structural damage that induced secondary epilepsy, genetic variants, and molecular alterations. In this review, we summarize several theories that may explain the genetic and molecular basis of epilepsy-related cognitive dysfunction. (C) 2019 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81601134, 81501025]; Yunnan Applied Basic Research Projects [2017FE468(-144)]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ3174]; Yunnan Provincial Key Projects [2017FA041]; Program for Science and Technology Innovation Team in Kunming Medical University [CXTD201614]; China Scholarship CouncilChina Scholarship Council
第一作者机构：[1]Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China[*1]Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China
推荐引用方式(GB/T 7714)：
Zhu Lin,Chen Lu,Xu Puying,et al.Genetic and molecular basis of epilepsy-related cognitive dysfunction[J].EPILEPSY & BEHAVIOR.2020,104:doi:10.1016/j.yebeh.2019.106848.
APA：
Zhu, Lin,Chen, Lu,Xu, Puying,Lu, Di,Dai, Shujuan...&Wu, Qian.(2020).Genetic and molecular basis of epilepsy-related cognitive dysfunction.EPILEPSY & BEHAVIOR,104,
MLA：
Zhu, Lin,et al."Genetic and molecular basis of epilepsy-related cognitive dysfunction".EPILEPSY & BEHAVIOR 104.(2020)
