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Subtypes of tumor-associated neutrophils and their roles in cancer immunotherapy

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机构: [1]Department of Hepatobiliary & Pancreatic Surgery, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650000, China [2]Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China [3]Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China [4]Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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关键词: Tumor-associated neutrophils Subgroups Reprogram Cancer immunotherapy Clinical translation

摘要:
Neutrophils are essential components of the innate immune system. Tumor-associated neutrophils (TANs) are shaped by tumor microenvironment (TME), leading to significant heterogeneity in biological characteristics and functions. Recent advances in single-cell sequencing have revealed a wide array of TAN subtypes, while a comprehensive classification system is still lacking. This review aims to summarize the alterations observed in TAN subgroups following cancer immunotherapy, and identify the distinctions and commonalities between pro-tumor and anti-tumor subgroups. Current progress of preclinical and clinical studies is also highlighted, involving novel therapies targeting TANs.Copyright © 2025 Elsevier B.V. All rights reserved.

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大类 | 2 区 医学
小类 | 2 区 血液学 2 区 肿瘤学
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Q1 HEMATOLOGY Q1 ONCOLOGY
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Q1 HEMATOLOGY Q1 ONCOLOGY

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第一作者机构: [1]Department of Hepatobiliary & Pancreatic Surgery, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650000, China [2]Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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通讯机构: [2]Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China [3]Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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