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Garlic-derived bioactive compound S-allylcysteine inhibits cancer progression through diverse molecular mechanisms

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收录情况： ◇ SCIE

作者：
Yannick Luther Agbana[a] * ; Yueli Ni[a] ; Meiling Zhou[a] ; Qiao Zhang[a] ; Kokouvi Kassegne[b] ; Simplice Damintoti Karou[c] ; Yingmin Kuang[d] ; Yuechun Zhu[a] ;
机构： [a]Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, People's Republic of China [b]Laboratory of Pathogen Infection and Immunity, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, JiangnanUniversity, Wuxi 214122, Jiangsu, People's Republic of China [c]Ecole Supérieure des Techniques Biologiques et Alimentaires, Université de Lomé, BP 1515, Lomé-Togo [d]Department of Organ Transplantation, The First Affiliated Hospital of Kunming Medical University, Wuhua District, Kunming 650032,Yunnan Province, People's Republic of China
出处：
DOI： 10.1016/j.nutres.2019.11.002
ISSN：

关键词： Garlic Cancer Apoptosis Cell Cycle DNA methyltransferase S-allylcysteine

摘要：
The purpose of this review is to discuss the molecular mechanisms underlying the anticancer properties of S-allylcysteine (SAC). Over the decades, evidence derived from in vitro and in vivo studies has shown that this predominant organosulfur component of aged garlic extract has multiple anticancer properties; hence, some potential mechanisms responsible for the anticarcinogenic action have been suggested. These mechanisms include induction of carcinogen detoxification, inhibition of cell proliferation and growth, mediation of cell cycle arrest, induction of cell death, inhibition of epithelial-mesenchymal transition and cell invasion, suppression of metastasis, and induction of immunomodulation in cancer cells. However, the actions and mechanisms are not comprehensive, and important aspects of the anticancer activities of SAC still need to be explored. In light of the current evidence, more specific studies, specifically clinical and epidemiological, are required to advance the promising use of SAC as a chemopreventive and therapeutic agent in cancer. (C) 2019 Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31660246, 81760455, 81560037]; Yunnan Province, Kunming Medical University joint Foundation for Applied Basic Research [2017FE468(-003), 2018FE468(-001), 2017FE468(-132)]
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外文
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 4 区 营养学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 营养学
JCR分区：
出版当年[2019]版：
Q3 NUTRITION & DIETETICS
最新[2023]版：
Q2 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, People's Republic of China
通讯作者：
推荐引用方式(GB/T 7714)：
Yannick Luther Agbana,Yueli Ni,Meiling Zhou,et al.Garlic-derived bioactive compound S-allylcysteine inhibits cancer progression through diverse molecular mechanisms[J].NUTRITION RESEARCH.2020,73:1-14.doi:10.1016/j.nutres.2019.11.002.
APA：
Yannick Luther Agbana,Yueli Ni,Meiling Zhou,Qiao Zhang,Kokouvi Kassegne...&Yuechun Zhu.(2020).Garlic-derived bioactive compound S-allylcysteine inhibits cancer progression through diverse molecular mechanisms.NUTRITION RESEARCH,73,
MLA：
Yannick Luther Agbana,et al."Garlic-derived bioactive compound S-allylcysteine inhibits cancer progression through diverse molecular mechanisms".NUTRITION RESEARCH 73.(2020):1-14

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