机构：[1]Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, China[2]Department of Stomatology, The First People's Hospital of Yunnan Provience, Kunming, 650500, China门急诊片口腔医学中心云南省第一人民医院[3]Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802[4]Department of Second Cardiology, The Third People's Hospital of Kunming, Kunming, 650500, China[5]Department of Neurology, The First Affiliated Hospital, Kunming Medical University, Kunming, 650500, China昆明医科大学附属第一医院[6]Department of Cardiology, The Second Affiliated Hospital, Kunming Medical University, Kunming, 650032, China
The extracellular matrix provides cells with a support structure and an attachment site in actual substrate. Its biochemical and surface properties play an important role in and have significant impact on cell attachment, proliferation, migration, differentiation, and gene expression. Leveraging the hydrophilicity and neuroprotective of gastrodin, a gastrodin/polyurethane (PU) elastomer was developed utilizing in situ polymerization and salt-leaching methods. The results showed that gastrodin/PU film had a good flexibility and supporting strength, as well as hydrophilicity. Thus film possessed highly surface area, interconnected porous structure with a pore size (10 similar to 60 mu m) for cell attachment, and could provide surface cues to augment neurite extension. For PC12 cells cultured within the films, especially the 5gastrodin/PU group, presented a progressive increase with time, coupled with the upregulation of brain-derived neurotrophic factor and glial cell derived neurotrophic factor expression. This is the first report on the construction of a gastrodin/PU porous film, and the results reveal its promise as a scaffold material for neural tissue engineering.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81360200/81460210/81860326]; Department of Science and Technology of Yunnan Province of China [2017FA035/2018FE001(-137)/2018FE001(-165)/2019ZF011-2]; International Science and Technology Cooperation Project of Yunnan Province [2018IA048]; Education Commission of Yunnan Province [2017zzx200/2018Y046]; Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province
第一作者机构：[1]Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, China
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推荐引用方式(GB/T 7714)：
Li Qing,Li Limei,Yu Mali,et al.Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration[J].JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.2020,108(8):1713-1725.doi:10.1002/jbm.a.36937.
APA：
Li, Qing,Li, Limei,Yu, Mali,Zheng, Meng,Li, Yao...&Lu, Di.(2020).Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,108,(8)
MLA：
Li, Qing,et al."Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 108..8(2020):1713-1725
