Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines
机构：[1]Department of Urology, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China外科片泌尿外科云南省第一人民医院[2]Department of Urology, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan, China[3]Department of Industrial Biotechnology, Bharath University, Chennai, Tamilnadu, India[4]R&D Wing, Lifeline Hospital, Chennai, Tamilnadu, India[5]Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia[6]Department of Surgery, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia[7]Department of Urological Surgery No.2, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院
Biosynthesis of silver nanoparticles (AgNPs) from the medicinal plants has been considered as a remarkable approach of several therapeutic innovations and successful drug delivery. Silver nanoparticles were biosynthesized with Salvia miltiorrhiza, Chinese medicinal herb and assessed for its anticarcinogenic property. Synthesis of AgNPs was characterized by several studies such as UV-absorbance and it shows peak values in the range of 425-445 nm. The sizes of the nanoparticles are confirmed by dynamic light scattering analysis and it shows 100 nm. Furthermore, transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX) was to confirm the shape and Ag particles are present in the synthesized materials. FTIR analysis to find out the active biomolecules located in the surface of the synthesized particles. This AgNPs from S. miltiorrhiza inhibits the growth of Bacillus subtillis, Staphylococcus aureus, Escherichia coli, and Klebsiella pneumonia. Furthermore, the anticancer potential of AgNPs is examined in prostate adenocarcinoma (LNCaP) cell lines. In this study, we found the AgNPs effectively induces cytotoxicity, ROS and apoptosis by modulation of intrinsic apoptoic Bcl2, Bclxl, Bax and Caspase 3 protein expressions in LNCap cell lines. Based on the study, synthesis of AgNPs from S. miltiorrhiza shows eco-friendly and it exhibits antimicrobial and anticarcinogenic effects.
第一作者机构：[1]Department of Urology, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China
通讯作者：
通讯机构：[7]Department of Urological Surgery No.2, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China[*1]Department of Urological Surgery. No.2, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China
推荐引用方式(GB/T 7714)：
Zhang Ke,Liu Xiaodong,Ravi Samson Oliver Abraham Samuel,et al.Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines[J].ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY.2019,47(1):2846-2854.doi:10.1080/21691401.2019.1638792.
APA：
Zhang, Ke,Liu, Xiaodong,Ravi, Samson Oliver Abraham Samuel,Ramachandran, Arunkumar,Ibrahim, Ibrahim Abdel Aziz...&Yao, Jiapei.(2019).Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,47,(1)
MLA：
Zhang, Ke,et al."Synthesis of silver nanoparticles (AgNPs) from leaf extract of Salvia miltiorrhiza and its anticancer potential in human prostate cancer LNCaP cell lines".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 47..1(2019):2846-2854
