机构:[1]Department of Neurology,West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, People’s Republic of China四川大学华西医院[2]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, 295 Xi Change Road, Kunming 650032, Yunnan Province, People’s Republic of China昆明医科大学附属第一医院[3]Department of Neurology, Seventh People’s Hospital of Chengdu, Chengdu, Sichuan Province, People’s Republic of China[4]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China四川大学华西医院
Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, appears to result from the combination of genetic and environmental factors. Whether the rs2275294 polymorphism in the ZNF512B gene influences ALS risk is controversial. We meta-analysed the association between rs2275294 and ALS risk based on evidence published in the PubMed database. Five case-control studies involving 2559 patients with sporadic ALS and 5740 controls were analysed. Based on random-effects meta-analysis, the polymorphism rs2275294 was associated with increased risk of ALS disease in an allele model (C vs. T: OR 1.222, 95%CI 1.057 to 1.414, p = 0.007). The available evidence suggests that the ZNF512B polymorphism rs2275294 is associated with ALS risk. These results should be validated in large, well-designed studies, especially in non-Asian populations.
基金:
Major Clinical Disease Research Program from the Health and Family Planning Commission of Sichuan Province [17ZD011]; Sichuan Key Project of Science and Technology [2010SZ0086]
第一作者机构:[1]Department of Neurology,West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, People’s Republic of China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Ning Pingping,Yang Xinglong,Yang Baiyuan,et al.Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis[J].NEUROLOGICAL SCIENCES.2018,39(7):1261-1266.doi:10.1007/s10072-018-3411-5.
APA:
Ning, Pingping,Yang, Xinglong,Yang, Baiyuan,Zhao, Quanzhen,Huang, Hongyan...&Xu, Yanming.(2018).Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis.NEUROLOGICAL SCIENCES,39,(7)
MLA:
Ning, Pingping,et al."Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis".NEUROLOGICAL SCIENCES 39..7(2018):1261-1266