机构:[1]Department of Anesthesia, First Affiliated Hospitalof Kunming Medical University, Kunming 650032, Yunnan,People’s Republic of China昆明医科大学附属第一医院[2]Department of Neurology, Seventh People’sHospital of Chengdu, Chengdu 690041, Sichuan,People’s Republic of China[3]Department of Geriatric Neurology, First Affiliated Hospitalof Kunming Medical University, Kunming 650032, Yunnan,People’s Republic of China昆明医科大学附属第一医院[4]Department of Neurology, West China Hospital, SichuanUniversity, Chengdu 610041, Sichuan, China四川大学华西医院[5]Department of Neurology, First Affiliated Hospitalof Kunming Medical University, Kunming 650032, Yunnan,People’s Republic of China昆明医科大学附属第一医院
The aim of this study is to explore whether the single nucleotide polymorphism rs2275294 in the ZNF512B gene is related to the length of survival of patients with amyotrophic lateral sclerosis (ALS). This prospective study examined 212 patients with ALS, who were genotyped at the rs2275294 locus in ZNF512B using the ligase method. Genotype was compared with clinical data and survival. Kaplan-Meier survival analysis and Cox hazard regression were used to identify risk factors of shorter survival. Our results were meta-analyzed together with previous work in order to examine the potential association between the rs2275294-C allele and survival. Of the 212 patients, 166 carried the CC + CT genotype at the rs2275294 locus, while 46 carried the TT genotype. Patients with the C allele showed significantly shorter survival than those without it (34.13 ± 1.9 vs. 45.32 ± 5.7 months, p = 0.036). Cox analysis identified the C allele and time from symptom onset to diagnosis as risk factors for shorter survival. Meta-analysis of 447 patients in China and Japan confirmed the rs2275294-C allele to be an independent risk factor of shorter survival in ALS patients. The C allele at the rs2275294 locus in ZNF512B is a risk factor for shorter survival in patients with ALS.
基金:
the National Natural
Science Foundation of China (81960242), Yunnan Applied Basic
Research Project (2019FE001-048,202001AT070001), Yunnan Provincial
Health Science and Technology Project (2018NS0102), The
Applied basic Research of The Diagnosis and Treatment Center of
Neurological Diseases in Yunnan Province (ZX2019-03-05), and 100
Young and Middle-aged Academic and Technical Scholars at Kunming
Medical University (60118260105).
第一作者机构:[1]Department of Anesthesia, First Affiliated Hospitalof Kunming Medical University, Kunming 650032, Yunnan,People’s Republic of China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Jiang Haixia,Yang Baiyuan,Wang Fang,et al.Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis.[J].NEUROMOLECULAR MEDICINE.2021,23(2):242-246.doi:10.1007/s12017-020-08634-y.
APA:
Jiang Haixia,Yang Baiyuan,Wang Fang,Li Kelu,Zhu Yongyun...&Yang Xinglong.(2021).Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis..NEUROMOLECULAR MEDICINE,23,(2)
MLA:
Jiang Haixia,et al."Association of Single Nucleotide Polymorphism at rs2275294 in the ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis.".NEUROMOLECULAR MEDICINE 23..2(2021):242-246