机构：[1]Department of Bone and Soft Tissue Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China[2]Department of Orthopedics, First Central Clinical College, Tianjin Medical University, Nankai District 300110, Tianjin, China.[3]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.昆明医科大学附属第一医院
Gastric adenocarcinoma predictive long intergenic non-coding (GAPLINC) is a novel long non-coding RNA (lncRNA) and has been found to function as an oncogenic lncRNA in gastric cancer, colorectal cancer, and bladder cancer. The expression status and biological function of GAPLINC in osteosarcoma are still unknown. Thus, we analyzed the association between GAPLINC expression and clinicopathological characteristics in osteosarcoma clinical samples, and conducted loss-of-function study in osteosarcoma cell lines. In our results, GAPLINC expression is elevated in osteosarcoma tissues and cell lines, and correlated with advanced Enneking stage, present distant metastasis, and poor histological grade. Survival analyses indicated that GAPLINC expression was negatively associated with overall survival, and GAPLINC high-expression was an independent risk factor in osteosarcoma patients. The in vitro studies showed knockdown of GAPLINC depressed osteosarcoma cell migration and invasion via inhibiting CD44 expression, but no effect on cell proliferation. In conclusion, GAPLINC may serve as a potential biomarker for predicting prognosis and developing therapy for osteosarcoma.
基金：
This study was funded by Scientific and Technological Project of Guangxi Province (No. 2016SF1063).
第一作者机构：[1]Department of Bone and Soft Tissue Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China
共同第一作者：
通讯作者：
通讯机构：[3]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.[*1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, No.295 Xichang Road, Kunming 650032, Yunnan, China
推荐引用方式(GB/T 7714)：
Liao Shian,Zhou Sijia,Wang Chao.GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma[J].BIOSCIENCE REPORTS.2018,38:doi:10.1042/BSR20181171.
APA：
Liao, Shian,Zhou, Sijia&Wang, Chao.(2018).GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma.BIOSCIENCE REPORTS,38,
MLA：
Liao, Shian,et al."GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma".BIOSCIENCE REPORTS 38.(2018)
