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Chinese systemic lupus erythematosus treatment and research group registry IX: Clinical features and survival of childhood-onset systemic lupus erythematosus in china(Open Access)

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 中华系列

作者:
机构: [1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China [2]Department of Rheumatology, Beijing Children Hospital Affiliated to Capital Medical University, Beijing 100045, China [3]Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China [4]Department of Rheumatology, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China [5]Department of Rheumatology, Tianjin Medical University General Hospital, Tianjin 300052, China [6]Department of Rheumatology, Capital Institute of Pediatrics, Beijing 100102, China [7]Department of Rheumatology, The Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510630, China [8]Peking Union Medical College Hospital [9]The Affiliated Drum Tower Hospital of Nanjing University Medical School [10]Anhui Provincial Hospital [11]The Affiliated Hospital of Bengbu Medical College [12]The First Affiliated Hospital of Sun Yat‑sen University [13]The Second Hospital of Shanxi Medical University [14]Beijing Hospital Affiliated to the Ministry of Health of PRC [15]China‑Japan Friendship Hospital Affiliated to the Ministry of Health of PRC [16]Beijing Chao‑Yang Hospital, Capital Medical University [17]Xuanwu Hospital Affiliated to Capital Medical University [18]Beijing Friendship Hospital Affiliated to Capital Medical University [19]Beijing Children Hospital Affiliated to Capital Medical University [20]Capital Institute of Pediatrics [21]Chinese People’s Liberation Army General Hospital [22]Changhai Hospital Affiliated to the Second Military Medical University [23]Changzheng Hospital Affiliated to the Second Military Medical University [24]Huashan Hospital Affiliated to Fudan University [25]The First Affiliated Hospital of Anhui Medical University [26]Qilu Hospital of Shandong University [27]The Second Affiliated Hospital of Zhejiang University School of Medicine [28]The Third Affiliated Hospital of Sun Yat‑sen University [29]The Second Affiliated Hospital of Guangzhou Medical College [30]Guangdong Provincial People’s Hospital [31]Xiangya Hospital, Central South University [32]The First Affiliated Hospital of Harbin Medical University [33]The First Hospital of China Medical University [34]Xijing Hospital Affiliated to the Fourth Military Medical University [35]The Second Hospital of Lanzhou University [36]West China Hospital Affiliated to Sichuan University [37]The Affiliated Hospital of North Sichuan Medical College [38]Sichuan Provincial People’s Hospital [39]The People’s Hospital of Xinjiang Autonomous Region [40]Jiangsu Provincial People’s Hospital [41]The First Affiliated Hospital of Zhengzhou University [42]Shengjing Hospital Affiliated to China Medical University [43]The First Affiliated Hospital of Shantou University Medical College [44]Tianjin First Central Hospital [45]The Affiliated Hospital of Bengbu Medical College [46]Peking University First Hospital [47]Peking University Shougang Hospital [48]Beijing Jishuitan Hospital [49]Fuxing Hospital Affiliated to Capital Medical University [50]Beijing Shunyi Hospital [51]Peking University Third Hospital [52]South‑West Hospital Affiliated to Third Military Medical University [53]The First People’s Hospital of Foshan [54]Fujian Provincial Hospital [55]The Second Affiliated Hospital of Fujian Medical University [56]Fuzhou General Hospital of Nanjing Military Region [57]Zhongshan Hospital Affiliated to Fudan University [58]The First Affiliated Hospital of Guangxi Medical University [59]The People’s Hospital of Guangxi Autonomous Region [60]The Affiliated Hospital of Guiyang Medical College [61]The Second Affiliated Hospital of Harbin Medical University [62]Hainan Provincial People’s Hospital [63]Hebei Provincial People’s Hospital [64]Bethune International Peace Hospital [65]Henan Provincial People’s Hospital [66]The First Hospital of Qiqihar [67]Tongji Hospital Affiliated to Tongji Medical School of Huazhong University of Science and Technology [68]Jiangxi Provincial People’s Hospital [69]No. 202 Hospital of People’s Liberation Army [70]The Affiliated Hospital of Inner Mongolia Medical College [71]Nanfang Hospital Affiliated to Southern Medical University [72]The General Hospital of Ningxia Medical University [73]The Affiliated Hospital of Qingdao University Medical College [74]The Fourth People’s Hospital of Shenzhen Affiliated to Guangdong Medical College [75]The General Hospital of Tianjin Medical University [76]Beijing Tongren Hospital Affiliated to Capital Medical University [77]The Second People’s Hospital of Wuxi [78]The People’s Hospital of Wuxi [79]The Second Xiangya Hospital of Central South University [80]The First People’s Hospital of Yunnan Province [81]The First Affiliated Hospital of Zhejiang University School of Medicine [82]Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University [83]The First People’s Hospital of Changzhou [84]The Affiliated Orthopaedic Hospital of Shandong Linyi People’s Hospital [85]Zhejiang Provincial People’s Hospital [86]The First Affiliated Hospital of Baotou Medical College [87]The Affiliated Hospital of Nantong University [88]The First Affiliated Hospital of Suzhou University [89]Beijing Shijitan Hospital [90]Shandong Yantai Yuhuangding Hospital [91]The General Hospital of Daqing Oilfield [92]First Affiliated Hospital of Medical College of Xi’an Jiaotong University [93]Provincial Hospital Affiliated to Shandong University, Jinan, China [94]Ji’nan University Second Clinical Medicine College, Shenzhen People’s Hospital [95]No. 285 Hospital of People’s Liberation Army [96]The First Hospital of Shanxi Medical University [97]Kailuan Hospital Affiliated to North China Coal Medical College [98]Peking University Shenzhen Hospital [99]The First Affiliated Hospital of Fujian Medical University [100]The First Hospital of Ningbo [101]Shanxi Provincial People’s Hospital [102]The Second Hospital of Hebei Medical University [103]The First Affiliated Hospital of Wenzhou Medical College [104]The Third Affiliated Hospital of Hebei Medical University [105]The First Affiliated Hospital of Xinjiang Medical University [106]Qingdao Municipal Hospital [107]Wuhan Union Hospital Affiliated to Tongji Medical School of Huazhong University of Science and Technology [108]No. 264 Hospital of People’s Liberation Army [109]Zhongda Hospital Affiliated to Southeast University [110]The Central Hospital of Sichuan Mianyang [111]The Seventh People’s Hospital of Shenyang
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关键词: Childhood Onset Outcomes Systemic Lupus Erythematosus

摘要:
Background: Approximately 15–20% cases of systemic lupus erythematosus (SLE) are diagnosed in children. There have been a few studies reporting the epidemiological data of pediatric-onset SLE (cSLE) in China, neither comparing the differences between cSLE and adult-onset SLE (aSLE). The aim of this study was to describe the impact of age of onset on clinical features and survival in cSLE patients in China based on the Chinese SLE Treatment and Research group (CSTAR) database. Methods: We made a prospective study of 225 cSLE patients (aged <16 years) and 1759 patients aged 16–50 years based on CSTAR registry. We analyzed initial symptoms, clinical presentations, SLE disease activity, damages, and outcomes of cSLE, as well as compared with aSLE patients. Results: The mean age of cSLE patients was 12.16 ± 2.92 years, with 187 (83.1%) females. Fever (P < 0.001) as well as mucocutaneous (P < 0.001) and renal (P = 0.006) disorders were found to be significantly more frequent in cSLE patients as initial symptoms, while muscle and joint lesions were significantly less common compared to aSLE subjects (P < 0.001). The cSLE patients were found to present more frequently with malar rash (P = 0.001; odds ratio [OR], 0.624; 95% confidence interval [CI ], 0.470–0.829) but less frequently with arthritis (P < 0.001; OR, 2.013; 95% CI, 1.512–2.679) and serositis (P = 0.030; OR, 1.629; 95% CI, 1.053–2.520). There was no significant difference in SLE disease activity index scores between cSLE and aSLE groups (P = 0.478). Cox regression indicated that childhood onset was the risk factor for organ damage in lupus patients (hazard ratio 0.335 [0.170–0.658], P = 0.001). The survival curves between the cSLE and aSLE groups had no significant difference as determined by the log-rank test (0.557, P = 0.455). Conclusions: cSLE in China has different clinical features and more inflammation than aSLE patients. Damage may be less in children and there is no difference in 5-year survival between cSLE and aSLE groups. © 2017 Chinese Medical Journal.

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基金编号: 2012AA020830 2008BAI59B02

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 医学:内科
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 医学:内科
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出版当年[2016]版:
Q3 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者:
第一作者机构: [1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China
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通讯作者:
通讯机构: [1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China [*1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
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