机构：[1]Institute of Neuroscience, Kunming Medical University, Yunnan Kunming, China[2]Second Department of General Surgery, First People’sHospital of Yunnan Province, Yunnan Kunming, China[3]First People’s Hospital of Honghe State, Yunnan Mengzi, China[4]Department ofNeurosurgery, First Affiliated Hospital of Kunming Medical University, Yunnan Kunming, China昆明医科大学附属第一医院[5]Department of Neurosurgery, First People’sHospital of Kunming City, Yunnan Kunming, China[6]School of Pharmacy and Medical Sciences, Sansom Institute, Faculty of Health Sciences,University of South Australia, Adelaide, Australia
Background: Alcohol abuse is a serious health problem worldwide that causes a variety of physical and mental disorders. Research has shown that the brain-derived neurotrophic factor (BDNF) plays an important role in alcohol addiction. The BDNF precursor (proBDNF) exhibits different actions than BDNF through separate receptors and pathways in the central nervous system. However, the effects of proBDNF and BDNF in alcohol addiction are not fully known. Objectives: The objective was to identify the expression patterns and effects of proBDNF and BDNF after chronic alcohol exposure. Methods: A total of 40 male adult mice were studied. A mouse psychomotor sensitization (PS) model was established to explore the effects of BDNF and proBDNF treatment following chronic alcohol exposure. Reverse transcription PCR (RT-PCR) was performed to measure mRNA levels for BDNF, TrkB, P75NTR, and sortilin in the prefrontal cortex, hippocampus, and dorsal striatum of Kunming mice after chronic alcohol exposure. Results: In Kunming mice, chronic alcohol exposure up-regulated BDNF and TrkB mRNA levels in the prefrontal cortex, but decreased sortilin and P75 mRNA levels in the dorsal striatum. No changes in mRNA levels were found in other measured brain regions in the alcohol and control groups. Conclusion: Chronic alcohol exposure induced the region-specific expression of BDNF and proBDNF and their respective receptors in the brain. These results suggest that BDNF and proBDNF signaling pathways may play major roles in alcohol preference and addiction.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China [31260253, 31560295]; Science Foundations of Education Department of Yunnan Province [2012Z151c]; Priority Union Foundation of Yunnan Provincial Science and Technology Department; Kunming Medical University [2013FB114]; Health Science and Technology Plan Projects of Yunnan Province [2014NS202]
第一作者机构：[1]Institute of Neuroscience, Kunming Medical University, Yunnan Kunming, China[2]Second Department of General Surgery, First People’sHospital of Yunnan Province, Yunnan Kunming, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Neuroscience, Kunming Medical University, Yunnan Kunming, China[2]Second Department of General Surgery, First People’sHospital of Yunnan Province, Yunnan Kunming, China[6]School of Pharmacy and Medical Sciences, Sansom Institute, Faculty of Health Sciences,University of South Australia, Adelaide, Australia[*1]Institute of Neuroscience, Kunming Medical University, 1168 Chunrong West Road, Kunming 650500, Yunnan P.R., China[*2]Second Department of General Surgery, First People’s Hospital of Yunnan Province, 157 Jinbi Road, Kunming 650032, Yunnan P.R., China[*3]School of Pharmacy and Medical Sciences, Sansom Institute, Faculty of Health Sciences, University of South Australia, Adelaide 5001, South Australia, Australia.
推荐引用方式(GB/T 7714)：
Yang Jin-Wei,Ma Wei,Yang Yan-lei,et al.Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure[J].AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE.2017,43(5):602-608.doi:10.1080/00952990.2016.1263642.
APA：
Yang, Jin-Wei,Ma, Wei,Yang, Yan-lei,Wang, Xian-bin,Li, Xing-tong...&Li, Li-yan.(2017).Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure.AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,43,(5)
MLA：
Yang, Jin-Wei,et al."Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure".AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE 43..5(2017):602-608
