机构：[1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China,[2]Department of Anesthesiology, the firstaffiliated hospital of Kunming Medical University, Kunming, Yunnan Province, China,[3]Department of Clinical Laboratory, Shanxi Tumor Hospital,Taiyuan, Shanxi, China,[4]Department of Medical Service, Unit 65176 of PLA, Dalian, Liaoning, China,[5]Department of Cardiology and ClinicalLaboratory, 211 Hospital of PLA, Harbin, Heilongjiang, China
To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung cancer patients; this implied that somatic mutations at D310 could be served as valuable biomarker for diagnostic of Chinese lung cancer. Further analyses indicated that deletion and heterogeneity were the predominant characters for somatic mutations detected at D310 of Chinese lung cancer patients.
第一作者机构：[1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China,
通讯作者：
通讯机构：[1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China,[*1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China
推荐引用方式(GB/T 7714)：
Chen Xian-Zhong,Fang Yu,Shi Yan-Hai,et al.Mitochondrial D310 instability in Chinese lung cancer patients[J].MITOCHONDRIAL DNA PART A.2016,27(2):1177-1180.doi:10.3109/19401736.2014.936426.
APA：
Chen, Xian-Zhong,Fang, Yu,Shi, Yan-Hai,Cui, Jing-Hui,Li, Long-Yan...&Ling, Bin.(2016).Mitochondrial D310 instability in Chinese lung cancer patients.MITOCHONDRIAL DNA PART A,27,(2)
MLA：
Chen, Xian-Zhong,et al."Mitochondrial D310 instability in Chinese lung cancer patients".MITOCHONDRIAL DNA PART A 27..2(2016):1177-1180
