机构：[1]Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, Yunnan Province, China[2]Department of endocrinology, the Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China[3]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan Province, , China[4]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China[5]KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China[6]Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University, Yunnan Province, China昆明医科大学附属第一医院[7]Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Previous work suggests that mitochondrial DNA (mtDNA) derived from the maternal genome has a close affinity with type 2 diabetes. This would support a familial pattern for type 2 diabetes. Thereby, we analyzed complete mtDNA genomes from two families, A and B, from Southwest China that demonstrated maternally inherited type 2 diabetes. Our data support that mtDNA lineages from families A and B belong to haplogroups A4 and D4h1, respectively. This suggests that maternally inherited type 2 diabetes with similar penetrances can arise in Chinese individuals with strikingly different maternal genetic backgrounds. Two private coding region mutations (G13759A in MT-ND5 and G15930A in tRNA-Thr) were identified in family B. Further evolutionary and phylogenetic analyses suggest that both these mutations have multiple origins and are unlikely to be disease causing.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81260135]; training fund of Young and Middle-Aged Academic Technology leaders in Yunnan Province [2011CI045]; fund of medical leader in Yunnan Province [D-201217]; Youth Innovation Promotion Association, Chinese Academy of Sciences
第一作者机构：[1]Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, Yunnan Province, China[2]Department of endocrinology, the Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, Yunnan Province, China[3]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan Province, , China[4]State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China[5]KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan Province, China[*1]State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China
推荐引用方式(GB/T 7714)：
Yang Ying,Zhou Taicheng,Peng Minsheng,et al.Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families[J].MITOCHONDRIAL DNA PART A.2016,27(3):2040-2044.doi:10.3109/19401736.2014.982552.
APA：
Yang, Ying,Zhou, Taicheng,Peng, Minsheng,Liu, Yongying,Li, Yiping...&Zhang, Yaping.(2016).Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families.MITOCHONDRIAL DNA PART A,27,(3)
MLA：
Yang, Ying,et al."Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families".MITOCHONDRIAL DNA PART A 27..3(2016):2040-2044
