机构：[1]Pharmaceutical College of Kunming Medical University, Kunming 650500, China[2]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China昆明医科大学附属第一医院[3]Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China昆明医科大学附属第一医院[4]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
The prostate transmembrane protein, androgen-induced 1 (PMEPA1) has been previously shown to promote solid malignancies in a variety of cancers, but the role and mechanisms of PMEPA1 in breast cancer has not been fully addressed. Here, we found that PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. Furthermore, transforming growth factor-beta (TGF-beta) treatment was also found to upregulate PMEPA1 expression and the CSC-enriched populations in triple-negative breast cancer cell lines. TGF-beta-induced PMEPA1 expression partially contributed to TGF-beta-induced breast CSC maintenance. These findings suggest that TGF-beta-PMEPA1 axis might provide new diagnosis and therapeutic targets for breast cancer treatment.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81272930, 81322038, 31260208, 81460401, U1132605]; Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research [XDA01040406]; West Light Foundation of the Chinese Academy of SciencesChinese Academy of Sciences; Department of Science and Technology of Yunnan Province-Kunming Medical University [4FB022]
第一作者机构：[1]Pharmaceutical College of Kunming Medical University, Kunming 650500, China[2]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Nie Zhi,Wang Chunyan,Zhou Zhongmei,et al.Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression[J].ACTA BIOCHIMICA ET BIOPHYSICA SINICA.2016,48(2):194-201.doi:10.1093/abbs/gmv130.
APA：
Nie, Zhi,Wang, Chunyan,Zhou, Zhongmei,Chen, Ceshi,Liu, Rong&Wang, Dianhua.(2016).Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,48,(2)
MLA：
Nie, Zhi,et al."Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 48..2(2016):194-201
