机构：[1]Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai[2]Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai[3]Laboratory Medicine, Peking Union Medical College Hospital, Beijing[4]Laboratory Medicine, The First Teaching Hospital of Xinjiang Medical University, Xinjiang[5]Laboratory Medicine, West China Hospital, Sichuan University, Sichuan四川大学华西医院[6]Laboratory Medicine, Children’s Hospital of Fudan University, Shanghai[7]Laboratory Medicine, The First Affiliated Hospital of Anhui Medical University, Anhui[8]Laboratory Medicine, Tongji Hospital of Huazhong University of Science and Techonology, Hubei华中科技大学同济医学院附属同济医院[9]Laboratory Medicine, Ruijin Hospital of Shanghai Jiaotong University, Shanghai[10]Laboratory Medicine, The First Hospital of China Medical University, Shenyang[11]Laboratory Medicine, General Hospital of Tianjin Medical University, Tianjin[12]Laboratory Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Zhejiang[13]Laboratory Medicine, The First Affiliated Hospital of Yunnan Medical University, Yunnan[14]Laboratory Medicine, The First Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia,[15]Laboratory Medicine, Gansu Province Hospital, Gansu[16]Laboratory Medicine, Children’s Hospital of Shanghai, Shanghai[17]Laboratory Medicine, Beijing Hospital, Beijing[18]Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou[19]Laboratory Medicine, The First Affiliated Hospital of Zhejiang University, Zhejiang浙江大学医学院附属第一医院[20]Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院
With the aim of gathering temporal trends on bacterial epidemiology and resistance from multiple laboratories in China, the CHINET surveillance system was organized in 2005. Antimicrobial susceptibility testing was carried out according to a unified protocol using the Kirby-Bauer method or automated systems. Results were analyzed according to Clinical and Laboratory Standards Institute (CLSI) 2014 definitions. Between 2005 and 2014, the number of bacterial isolates ranged between 22 774 and 84 572 annually. Rates of extended-spectrum beta-lactamase production among Escherichia coli isolates were stable, between 51.7 and 55.8%. Resistance of E. coli and Klebsiella pneumoniae to amikacin, ciprofloxacin, piperacillin/tazobactam and cefoperazone/sulbactam decreased with time. Carbapenem resistance among K. pneumoniae isolates increased from 2.4 to 13.4%. Resistance of Pseudomonas aeruginosa strains against all of antimicrobial agents tested including imipenem and meropenem decreased with time. On the contrary, resistance of Acinetobacter baumannii strains to carbapenems increased from 31 to 66.7%. A marked decrease of methicillin resistance from 69% in 2005 to 44.6% in 2014 was observed for Staphylococcus aureus. Carbapenem resistance rates in K. pneumoniae and A. baumannii in China are high. Our results indicate the importance of bacterial surveillance studies. Clinical Microbiology and Infection (C) 2016 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.
基金：
Pfizer Investigator Initiated Research [WI207259]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273559]
第一作者机构：[1]Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai[*1]Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M. Wulumuqi Road, Shanghai 200040, China
推荐引用方式(GB/T 7714)：
F.-P. Hu,Y. Guo,D.-M. Zhu,et al.Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005-2014[J].CLINICAL MICROBIOLOGY AND INFECTION.2016,22:S9-S14.doi:10.1016/j.cmi.2016.01.001.
APA：
F.-P. Hu,Y. Guo,D.-M. Zhu,F.Wang,X.-F. Jiang...&W. Huang.(2016).Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005-2014.CLINICAL MICROBIOLOGY AND INFECTION,22,
MLA：
F.-P. Hu,et al."Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005-2014".CLINICAL MICROBIOLOGY AND INFECTION 22.(2016):S9-S14
医学