机构：[1]Department of Thoracic Surgery, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province, China[2]Institute of Medical Physics and Engineering, Tsinghua University, Beijing, China[3]Department of Biochemistry and Molecular Biology, China-Japan Friendship Institute of Clinical Medical Sciences, Beijing, China[4]Department of Thoracic Surgery, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan Province, China昆明医科大学附属第一医院
Purpose: The aim of this study was to investigate the effect of a higher temperature on the efficacy of magnetic fluid hyperthermia for Lewis lung cancer in a mouse model. Materials and methods: Magnetic fluidswere prepared in vitro and directly injected into tumors. Twenty-four hours later, the micewere subjected to an alternating magnetic field. The temperature in the tumor was increased to 46.0 C, higher than the usual temperature used in hyperthermia therapy. The higher temperature was maintained for 30 min with a stable strength of magnetic field. Results: Magnetic fluid hyperthermia with a higher temperature significantly inhibited the growth of the tumors (P < 0.05). The tumors completely regressed in four out of 12 mice. Histological analysis demonstrated that the tumor cells underwent apoptosis and necrosis, and the cellswere arrested at the G(1)/G(0) phase of the cell cycle. The lifespan of the treated animals also increased significantly (P < 0.05). Conclusions: Magnetic fluid hyperthermia with a higher temperature could improve the efficacy of this therapy on lung cancer.
基金：
National Nature Science Foundation of ChinaNational Natural Science Foundation of China [10775085, 30571779]; Science Committee Fund of Beijing [Z07000200540704]; Tsinghua University [20240000519]
第一作者机构：[1]Department of Thoracic Surgery, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province, China
通讯作者：
通讯机构：[2]Institute of Medical Physics and Engineering, Tsinghua University, Beijing, China[*1]Institute of Medical Physics &Engineering, Tsinghua University, Haidian District, Beijing 100084, China.
推荐引用方式(GB/T 7714)：
Runlei Hu,Xiaodong Zhang,Xuan Liu,et al.Higher temperature improves the efficacy of magnetic fluid hyperthermia for Lewis lung cancer in a mouse model[J].THORACIC CANCER.2012,3(1):34-39.doi:10.1111/j.1759-7714.2011.00075.x.
APA：
Runlei Hu,Xiaodong Zhang,Xuan Liu,Bo Xu,Hongsheng Yang...&Jintian Tang.(2012).Higher temperature improves the efficacy of magnetic fluid hyperthermia for Lewis lung cancer in a mouse model.THORACIC CANCER,3,(1)
MLA：
Runlei Hu,et al."Higher temperature improves the efficacy of magnetic fluid hyperthermia for Lewis lung cancer in a mouse model".THORACIC CANCER 3..1(2012):34-39
